Oxidative Stress as the Main Target in Diabetic Retinopathy Pathophysiology

Figure 1

Damage at each retinal layer. A series of events occur in early DR development. Neurodegeneration of horizontal, bipolar, amacrine, and ganglion cells. These damages may be determined by proNGF concentrations as NLRP3 and NLRP1 are related to eye degenerative diseases. NFL: nerve fiber layer; GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer; PL: photoreceptor layer.