Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2/HO-1 and NF-κB Pathways
Evaluation of isolated islet viability and function and change in blood glucose in each group. (a) Viability evaluation of isolated islets (FDA-PI staining: ×200). . (b) Stable colonization of transplanted islets under the kidney capsule (HE staining: ×200). . (c) Massive release of insulin after transplantation (immunohistochemical staining: ×200). . (d) Body weight changes over 16 weeks for each group. (e) Rat blood glucose changes over 16 weeks for each group (islet transplantation model rats established at 12 weeks). DM: diabetes mellitus; INS: insulin treatment; IT: islet transplantation.
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