Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes

Table 2

Clinical characteristics of the study samples.

Parameters	Total	Non-DKD group	DKD group	value
	1340	744	596
Male/female	637/703	304/440	333/263	<0.0001
Age (years)	64 (55, 72)	64 (56, 72)	64 (54, 73)	0.4578
Duration of diabetes (years)	10 (7, 14)	10 (8, 14)	9 (3, 14)	<0.0001
BMI (kg/m^2)	24.3 (21.9, 26.7)	23.7 (21.6, 26.2)	24.9 (22.3, 27.2)	<0.0001
SBP (mmHg)	135 (120, 150)	130 (120, 150)	140 (130, 150)	<0.0001
DBP (mmHg)	80 (75, 90)	80 (70, 85)	80 (80, 90)	<0.0001
HbA1c (%)	8.7 (7.3, 10.3)	8.3 (7.1, 10.0)	9.1 (7.5, 10.9)	<0.0001
AER (mg/24 h)	21.0 (8.4, 77.2)	9.2 (6.4, 14.5)	89.3 (46.3, 288.8)	<0.0001
eGFR (mL/min/1.73 m^2)	116.5 (94.4, 140.7)	120.7 (102.8, 141.8)	108.9 (81.2, 136.3)	<0.0001
Uric acid (μmol/L)	309 (250, 371)	293 (241, 351)	330 (271, 397)	<0.0001
Creatinine (μmol/L)	68 (56, 83)	64 (54, 75)	74 (59, 96)	<0.0001
Blood urea nitrogen (mmol/L)	5.8 (4.9, 7.1)	5.7 (4.8, 6.8)	6.1 (4.9, 7.8)	<0.0001
TC (mmol/L)	4.6 (4.1, 5.4)	4.6 (4.0, 5.2)	4.7 (4.1, 5.5)	0.0003
TG (mmol/L)	1.4 (1.0, 2.1)	1.3 (0.9, 1.9)	1.6 (1.0, 2.3)	<0.0001

Data are shown as median (interquartile range) or . value refers to the comparison of parameters between the DKD group and the non-DKD group. values < 0.05 are shown in bold. DKD: diabetic kidney disease; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; AER: 24-hour urinary albumin excretion rate; eGFR: estimated glomerular filtration rate; TC: total cholesterol; TG: total triglycerides.