Figure 7: An excess of peroxynitrite (ONOO-) may lead to Kv-mediated vasodilatation impairment through Kv1.2 tyrosine residue nitration; 4-hydroxynonenal (4-HNE) targets a cysteine 621 residue of the TRPV1 coronary channel impairing its function and contributing to CMD in diabetes mellitus.