Research Article

Distinct Effects of Carrageenan and High-Fat Consumption on the Mechanisms of Insulin Resistance in Nonobese and Obese Models of Type 2 Diabetes

Figure 1

Increases in glucose and insulin follow exposure to carrageenan and HFD. (a) Fasting blood glucose levels increased following carrageenan and high-fat exposures, and the combined exposure following 50 weeks of treatment was significantly great (, ). Carrageenan exposure had less effect on glucose levels than the HFD. (b) The corresponding fasting insulin levels were increased in the test animals, compared to controls (, ). (c) The measured glucose-stimulated insulin secretion declined following carrageenan and HFD and by their combination. CGN = carrageenan; GSIS = glucose-stimulated insulin secretion.