Effect of the Interaction between Obstructive Sleep Apnea and Lipoprotein(a) on Insulin Resistance: A Large-Scale Cross-Sectional Study

Table 3

The odds ratios for the presence of insulin resistance across AHI or Lp(a) quartiles.

	Quartile 1	Quartile 2	Quartile 3	Quartile 4	P for linear trend
AHI quartiles
n (cases/participants)	169/1,053	334/1,031	424/1,017	668/1,051	—
Unadjusted	1	2.51 (2.03, 3.10)	3.74 (3.05, 4.61)	9.12 (7.43, 11.25)	<0.001
Adjusted	1	1.61 (1.27, 2.05)	1.92 (1.50, 2.46)	2.87 (2.23, 3.70)	<0.001
Lp(a) quartiles
n (cases/participants)	456/1,026	427/1,062	371/1,032	341/1,032	—
Unadjusted	1.62 (1.36, 1.94)	1.35 (1.14, 1.63)	1.14 (0.95, 1.36)	1	<0.001
Adjusted	1.40 (1.12, 1.74)	1.21 (0.98, 1.50)	1.16 (0.93, 1.43)	1	0.029

Odds ratios, 95% confidence intervals, and P values were calculated using logistic regression analyses. Insulin resistance was defined as the HOMA-IR index > 3. AHI quartiles 1-4 correspond to the AHI range of ≤7, 7.1-28, 28.1-57, and >57 events/h, respectively. Lp(a) quartiles 1-4 correspond to the serum Lp(a) concentration range of ≤3.90, 3.91-7.40, 7.41-15.10, and >15.10 mg/dL, respectively. Adjusted variables include Lp(a) or AHI quartiles, age, gender, BMI, waist-to-hip circumference ratio, MAP, current smoking status, current drinking status, TC, TG, HDL-C, LDL-C, ApoA-I, and ApoB.