Serum Irisin Levels, Endothelial Dysfunction, and Inflammation in Pediatric Patients with Type 2 Diabetes Mellitus and Metabolic Syndrome

Figure 3

Correlation heat map for irisin and adhesion molecules with cytokine profile in children and adolescents with type 2 diabetes mellitus, metabolic syndrome, and healthy controls. Colored squares of the heat map represent Spearman’s rho correlation coefficients; the coefficients’ font appears black and bold when correlations are statistically significant and grey when they are not. Squares filled in shades of blue represent negative correlations, while those filled in shades of red represent positive correlations. Statistical significance was established as value ≤ 0.05. IL: interleukin; IFN: interferon; TNF: tumor necrosis factor; MCP: monocyte chemoattractant protein; sICAM: soluble intercellular adhesion molecule; sPSGL: soluble P-selectin glycoprotein ligand; sEpCAM: soluble epithelial cell adhesion molecule; sALCAM: soluble activated leukocyte cell adhesion molecule; sPECAM: soluble platelet endothelial cell adhesion molecule; sVCAM: soluble vascular cell adhesion molecule; sNCAM: soluble neural cell adhesion molecule.