Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency

<div>VAD induces inflammatory responses in the intestine by activating the NF-<i>κ</i>B signaling pathway. (a) Representative photomicrographs of intestinal sections of mice from VAS, VAD, and VADR groups using H &amp; E staining. (b) Plasma LPS and TNF-<i>α</i> concentrations were analyzed of mice described for (a) by ELISA. (c, d) PCR measurements of relative intestinal inflammation markers (TNF-<i>α</i>, IFN-<i>γ</i>, IL-6, and IL-1<i>β</i>) and tight-junction integrity markers (ZO-1, occludin) of mice described for (a). (e) The protein levels in NF-<i>κ</i>B signal pathways were analyzed of mice described for (a) using western blotting. (f) The protein levels of IKK were analyzed of mice described for (a) using ELISA. 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Journal of Diabetes Research

fig5

Figure 5

Figure 5: Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency 