Association of Maternal Diabetes Mellitus and Polymorphisms of the NKX2.5 Gene in Children with Congenital Heart Disease: A Single Centre-Based Case-Control Study

Table 4

Univariate analysis of NKX2.5 gene polymorphism and CHD.

SNP of NKX2.5 gene	Control group ()	Case group ()	Univariate analysis	Unadjusted OR (95% CI)
Genotype at rs6882776				0.98 (0.83-1.16)
A/A	216 (34.8%)	209 (33.7%)	;	1
G/A	308 (49.7%)	328 (52.9%)		1.10 (0.86-1.41)
G/G	96 (15.5%)	83 (13.4%)		0.89 (0.63-1.27)
Recessive model at rs6882776
A/A	216 (34.8%)	209 (33.7%)	;	1
G/A+G/G	404 (65.2%)	411 (66.3%)		1.05 (0.83-1.33)
Dominant model at rs6882776
A/A+ G/A	524 (84.5%)	537 (86.6%)	;	1
G/G	96 (15.5%)	83 (13.4%)		0.84 (0.61-1.16)
Allele at rs6882776
A	740 (59.7%)	746 (60.2%)	;	1
G	500 (40.3%)	494 (39.8%)		0.98 (0.84-1.15)
Genotype at rs118026695				1.83 (1.42-2.36)
T/T	510 (82.3%)	443 (71.5%)	;	1
C/T	107 (17.3%)	164 (26.5%)		1.77 (1.34-2.32)
C/C	3 (0.5%)	13 (2.1%)		4.99 (1.41-17.62)
Recessive model at rs118026695
T/T	510 (82.3%)	443 (71.5%)	;	1
C/T+C/C	110 (17.7%)	177 (28.5%)		1.85 (1.41-2.43)
Dominant model at rs118026695
T/T+C/T	617 (99.5%)	607 (97.9%)	;	1
C/C	3 (0.5%)	13 (2.1%)		4.41 (1.25-15.53)
Allele at rs118026695
T	1127 (90.9%)	1050 (84.7%)	;	1
C	113 (9.1%)	190 (15.3%)		1.81 (1.41-2.31)
Genotype at rs2277923				1.38 (1.17-1.62)
C/C	291 (46.9%)	217 (35.0%)	;	1
T/C	254 (41.0%)	310 (50.0%)		1.64 (1.29-2.08)
T/T	75 (12.1%)	93 (15.0%)		1.66 (1.17-2.36)
Recessive model at rs2277923
C/C	291 (46.9%)	217 (35.0%)	;	1
T/C+T/T	329 (53.1%)	403 (65.0%)		1.64 (1.31-2.06)
Dominant model at rs2277923
C/C+T/C	545 (87.9%)	527 (85.0%)	;	1
T/T	75 (12.1%)	93 (15.0%)		1.28 (0.93-1.78)
Allele at rs2277923
C	836 (67.4%)	744 (60.0%)	;	1
T	404 (32.6%)	496 (40.0%)		1.38 (1.17-1.63)
Genotype at rs703752				1.66 (1.20-2.29)
A/A	7 (1.1%)	2 (0.3%)	(Fisher’s exact test)	1
C/A	86 (13.9%)	57 (9.2%)		2.32 (0.47-11.57)
C/C	527 (85.0%)	561 (90.5%)		3.73 (0.77-18.02)
Recessive model at rs703752
A/A+C/A	93 (15.0%)	59 (9.5%)	;	1
C/C	527 (85.0%)	561 (90.5%)		1.68 (1.19-2.38)
Dominant model at rs703752
A/A	7 (1.1%)	2 (0.3%)	(Fisher’s exact test)	1
C/A+C/C	613 (98.9%)	618 (99.7%)		3.53 (0.73-17.05)
Allele at rs703752
A	100 (8.1%)	61 (4.9%)	; P =0.001	1
C	1140 (91.9%)	1179 (95.1%)		1.70 (1.22-2.36)

OR: odds ratio; CI: confidence interval. Statistically significant ().