Association of Maternal Diabetes Mellitus and Polymorphisms of the NKX2.5 Gene in Children with Congenital Heart Disease: A Single Centre-Based Case-Control Study
Table 6
Interaction analysis of Maternal DM and NKX2.5 on CHD in offspring.
Maternal DM
Genotype
β
value
Adjusted OR (95% CI)
GDM during this pregnancy
rs118026695
No
T/T
1
No
C/T
0.804(βg1)
0.001
2.23 (1.50-3.33)
No
C/C
21.324(βg2)
0.998
1.823E9
Yes
T/T
1.987(βe1)
0.001
7.29 (3.29-16.17)
Yes
C/T
2.094(βe1g1)
0.008
8.12 (1.71-38.51)
Yes
C/C
0.430(βe1g2)
0.620
1.54 (0.28-8.40)
GDM in previous pregnancy experiences
rs118026695
No
T/T
1
No
C/T
0.861(βg1)
0.001
2.37 (1.59-3.52)
No
C/C
1.496(βg2)
0.046
4.46 (1.03-19.44)
Yes
T/T
1.603(βe1)
0.001
4.97 (2.44-10.11)
Yes
C/T
1.681(βe1g1)
0.074
5.37 (0.85-33.87)
Yes
C/C
21.345(βe1g2)
0.999
1.862E9
PGDM in the 3 months before this pregnancy
rs118026695
No
T/T
1
No
C/T
0.826(βg1)
0.001
2.29 (1.54-3.40)
No
C/C
1.753(βg2)
0.013
5.77 (1.45-23.05)
Yes
T/T
1.971(βe1)
0.001
7.18 (3.27-15.74)
Yes
C/T
20.740(βe1g1)
0.998
1.017E9
Yes
C/C
GDM during this pregnancy
rs2277923
No
C/C
1
No
T/C
0.472(βg1)
0.007
1.60 (1.14-2.26)
No
T/T
0.703(βg2)
0.006
2.02 (1.22-3.34)
Yes
C/C
1.984(βe1)
0.001
7.27 (2.37-22.33)
Yes
T/C
2.875(βe1g1)
0.001
17.72 (5.79-54.24)
Yes
T/T
0.338(βe1g2)
0.628
1.40 (0.36-5.50)
GDM in previous pregnancy experiences
rs2277923
No
C/C
1
No
T/C
0.628(βg1)
0.001
1.88 (1.33-2.65)
No
T/T
0.715(βg2)
0.004
2.05 (1.25-3.34)
Yes
C/C
3.255(βe1)
0.001
25.92 (7.20-93.26)
Yes
T/C
1.225(βe1g1)
0.005
3.41 (1.44-80.07)
Yes
T/T
0.867(βe1g2)
0.317
2.38 (0.44-12.99)
PGDM in the 3 months before this pregnancy
rs2277923
No
C/C
1
No
T/C
0.579(βg1)
0.001
1.79 (1.27-2.52)
No
T/T
0.644(βg2)
0.009
1.90 (1.17-3.09)
Yes
C/C
3.592(βe1)
0.001
36.30 (7.62-172.98)
Yes
T/C
1.421(βe1g1)
0.002
4.14 (1.67-10.27)
Yes
T/T
21.312(βe1g2)
0.999
1.802E9
DM: diabetes mellitus; CHD: congenital heart disease; GDM: gestational diabetes mellitus; PGDM: pregestational diabetes mellitus; OR: odds ratio; CI: confidence interval. Adjusted for factors with statistical differences in Table 1.
