Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease

Figure 2

The overlapping pathology between diabetes mellitus (DM) and Alzheimer’s disease (AD). Due to many shared characteristics with impaired insulin signaling pathways, AD may be a metabolic disease. Metabolic changes including glucose/lipid metabolism, mitochondrial dysfunction, oxidative stress, and protein changes resulting from DM are associated with an impaired insulin signaling pathway. These metabolic factors could increase the prevalence of AD in diabetic patients, mainly by promoting Aβ pathology.