IgG Glycosylation Profile and the Glycan Score Are Associated with Type 2 Diabetes in Independent Chinese Populations: A Case-Control Study
Table 2
Associations of the IgG glycans and glycan score for type 2 diabetes in the discovery and replication populations and meta-analyses.
Glycan peak
Glycan structurea
Discovery population ()
Replication population ()
Meta-analyses
OR
valueb
OR
valueb
OR
valueb
Upregulated
GP22
A2BG2S2
2.520
<0.0001
2.535
<0.0001
2.531
<0.0001
GP24
FA2BG2S2
3.611
<0.0001
3.533
<0.0001
3.556
<0.0001
IGP32
FBG2S2/(FBG2+FBG2S1+FBG2S2)
5.392
<0.0001
8.717
<0.0001
6.621
<0.0001
IGP42
GP2n
1.542
0.0003
3.826
<0.0001
1.913
<0.0001
IGP45
GP6n
1.793
<0.0001
5.668
<0.0001
2.132
<0.0001
IGP60
FG1n total/G1n
4.038
<0.0001
4.551
<0.0001
4.349
<0.0001
Downregulated
<0.0001
GP3
A2B
0.392
<0.0001
0.351
<0.0001
0.361
<0.0001
GP5
M5
0.106
<0.0001
0.021
<0.0001
0.026
<0.0001
GP20
FA2FG2S1
0.158
<0.0001
0.017
<0.0001
0.020
<0.0001
IGP46
GP7n
0.232
<0.0001
0.183
<0.0001
0.195
<0.0001
IGP47
GP8n
0.510
<0.0001
0.272
<0.0001
0.313
<0.0001
IGP69
FBG2n/G2n
0.350
<0.0001
0.486
<0.0001
0.435
<0.0001
Glycan score
—
3.309
<0.0001
7.145
<0.0001
3.782
<0.0001
aStructure abbreviations: F: core fucose; A: number of antennas; B: bisecting GlcNAc; M: number of mannose residues; Gx: number of galactoses; Sx: number of sialic acids linked to galactose; n: neutral glycans. b values < 6.41-4 was considered statistically significant.