Research Article

IgG Glycosylation Profile and the Glycan Score Are Associated with Type 2 Diabetes in Independent Chinese Populations: A Case-Control Study

Table 2

Associations of the IgG glycans and glycan score for type 2 diabetes in the discovery and replication populations and meta-analyses.

Glycan peakGlycan structureaDiscovery population ()Replication population ()Meta-analyses
OR valuebOR valuebOR valueb

Upregulated
 GP22A2BG2S22.520<0.00012.535<0.00012.531<0.0001
 GP24FA2BG2S23.611<0.00013.533<0.00013.556<0.0001
 IGP32FBG2S2/(FBG2+FBG2S1+FBG2S2)5.392<0.00018.717<0.00016.621<0.0001
 IGP42GP2n1.5420.00033.826<0.00011.913<0.0001
 IGP45GP6n1.793<0.00015.668<0.00012.132<0.0001
 IGP60FG1n total/G1n4.038<0.00014.551<0.00014.349<0.0001
Downregulated<0.0001
 GP3A2B0.392<0.00010.351<0.00010.361<0.0001
 GP5M50.106<0.00010.021<0.00010.026<0.0001
 GP20FA2FG2S10.158<0.00010.017<0.00010.020<0.0001
 IGP46GP7n0.232<0.00010.183<0.00010.195<0.0001
 IGP47GP8n0.510<0.00010.272<0.00010.313<0.0001
 IGP69FBG2n/G2n0.350<0.00010.486<0.00010.435<0.0001
Glycan score3.309<0.00017.145<0.00013.782<0.0001

aStructure abbreviations: F: core fucose; A: number of antennas; B: bisecting GlcNAc; M: number of mannose residues; Gx: number of galactoses; Sx: number of sialic acids linked to galactose; n: neutral glycans. b values < 6.41-4 was considered statistically significant.