Association between PNPLA2 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in a Chinese Han Population with Type 2 Diabetes

Table 3

Genetic model analyses of the association between PNPLA2 polymorphisms and DKD with adjustment for confounders.

	Genetic models	Genotype	DM	DKD	Without adjustment		With adjustment^¶
					OR (95% CI)		OR (95% CI)
PNPLA2 rs28633403	Additive	AA	117 (26.7%)	136 (35.9%)	1^#	—	1^#	—
		AG	224 (51.0%)	169 (44.6%)	0.649 (0.472-0.892)	0.008	0.633 (0.447-0.895)	0.010
		GG	98 (22.3%)	74 (19.5%)	0.650 (0.440-0.960)	0.030	0.588 (0.385-0.897)	0.014
	Dominant	AA	117 (26.7%)	136 (35.9%)	1^#	—	1^#	—
		AG+GG	322 (73.3%)	243 (64.1%)	0.649 (0.482-0.875)	0.004	0.619 (0.447-0.857)	0.004
	Recessive	AA+AG	341 (77.7%)	305 (80.5%)	1^#	—	1^#	—
		GG	98 (22.3%)	74 (19.5%)	0.844 (0.601-1.185)	0.328	0.778 (0.540-1.121)	0.177
PNPLA2 rs1138714	Additive	AA	225 (51.3%)	159 (42.0%)	1^#	—	1^#	—
		AG	180 (41.0%)	185 (48.8%)	1.454 (1.090-1.941)	0.011	1.529 (1.118-2.091)	0.008
		GG	34 (7.7%)	35 (9.2%)	1.457 (0.871-2.435)	0.151	1.545 (0.888-2.688)	0.124
	Dominant	AA	225 (51.3%)	159 (42.0%)	1^#	—	1^#
		AG+GG	214 (48.7%)	220 (58.0%)	1.455 (1.103-1.919)	0.008	1.531 (1.134-2.067)	0.005
	Recessive	AA+AG	405 (92.3%)	344 (90.8%)	1^#	—	1^#	—
		GG	34 (7.7%)	35 (9.2%)	1.212 (0.740-1.985)	0.445	1.257 (0.739-2.138)	0.399
PNPLA2 rs1138693	Additive	TT	178 (40.5%)	157 (41.4%)	1^#		1^#
		TC	204 (46.5%)	173 (45.6%)	0.961 (0.716-1.292)	0.794	0.915 (0.663-1.263)	0.590
		CC	57 (13.0%)	49 (12.9%)	0.975 (0.629-1.510)	0.908	0.918 (0.573-1.469)	0.720
	Dominant	TT	178 (40.5%)	157 (41.4%)	1^#	—	1^#	—
		TC+CC	261 (59.5%)	222 (58.6%)	0.964 (0.729-1.275)	0.799	0.916 (0.675-1.242)	0.572
	Recessive	TT+TC	382 (87.0%)	330 (87.1%)	1^#	—	1^#	—
		CC	57 (13.0%)	49 (12.9%)	0.995 (0.661-1.498)	0.981	0.962 (0.621-1.491)	0.864

Abbreviations: ORs: odds ratios; CI: confidence interval. ^#Reference category (odds ratio, 1.0); adjustment for age, BMI, SBP, DBP, A1C, Hcy, TC, and TG; value < 0.05 indicates statistical significance.