Enterotype Bacteroides Is Associated with a High Risk in Patients with Diabetes: A Pilot Study
Table 2
Logistic regression analysis of the association of enterotypes with T2D risk.
(a)
Characteristics
Model 1
value
Model 2
value
Model 3
value
OR (95% CI)
OR (95% CI)
OR (95% CI)
ET B
4.100 (1.842–9.124)
0.001
4.362 (1.820–10.454)
0.001
3.124 (1.121–8.705)
0.029
Male
—
—
3.002 (1.268–7.109)
0.012
1.218 (0.435–3.408)
0.708
Age (years)
—
—
1.057 (1.022–1.093)
0.001
1.066 (1.023–1.111)
0.003
BMI (kg/m2)
—
—
1.006 (0.909–1.113)
0.911
0.928 (0.830–1.037)
0.188
TG (mmol/l)
—
—
1.604 (1.030–2.497)
0.037
HDL-C (mmol/l)
—
—
0.038 (0.008–0.184)
<0.001
(b)
Characteristics
Model 4
value
Model 5
value
Model 6
value
OR (95% CI)
OR (95% CI)
OR (95% CI)
ET B
4.668 (1.298–16.786)
0.018
3.096 (1.096–8.742)
0.033
5.786 (0.935–35.801)
0.059
Male
1.871 (0.560–6.254)
0.309
1.218 (0.434–3.416)
0.708
2.141 (0.371–12.347)
0.394
Age (years)
1.059 (1.006–1.114)
0.029
1.065 (1.021–1.110)
0.003
1.070 (1.001–1.144)
0.047
BMI (kg/m2)
0.918 (0.810–1.041)
0.183
0.929 (0.828–1.043)
0.047
—
—
TG (mmol/l)
1.760 (1.030–3.006)
0.038
1.612 (1.032–2.518)
0.036
0.915 (0.658–1.273)
0.915
HDL-C (mmol/l)
0.014 (0.002–0.107)
<0.001
0.037 (0.007–0.191)
<0.001
0.170 (0.016–1.808)
0.170
HOMA-β
0.956 (0.938–0.974)
<0.001
—
—
—
—
HOMA-IR
—
—
0.903 (0.386–2.112)
0.814
—
—
Gutt-ISI
—
—
—
—
0.000 (0.000–0.000)
<0.001
Model 1 had no adjusted variable. Model 2 is adjusted for age, gender, and BMI. Model 3 is adjusted for model 2 plus TG and HDL-C. Model 4 is adjusted for model 3 plus HOMA-β. Model 5 is adjusted for model 3 plus HOMA-IR. Model 6 is adjusted for model 3 plus Gutt-ISI, since body weight was used to calculate Gutt-ISI, BMI was removed in Model 6. . ET B: enterotype Bacteroides; BMI: body mass index; TGs: triglyceride levels; HDL-C: high-density lipoprotein cholesterol; HOMA-β: homeostasis model assessment of β-cell function; HOMA-IR: homeostasis model assessment of insulin resistance; Gutt-ISI: Gutt-insulin sensitivity index.
