Journal of Diabetes Research / 2020 / Article / Tab 2 / Review Article
The Role of Recombinant Proteins and Growth Factors in the Management of Diabetic Foot Ulcers: A Systematic Review of Randomized Controlled Trials Table 2 Outcomes of RCTs that evaluated PDGF safety and effectiveness.
Ref Type of growth factor Wound closure Mean time to heal in treatment groups Mechanism mentioned as complete healing Confounders Further outcomes Granulation tissue Reepithelialization Sex Baseline HbA1c Wound size Offloading Recurrence rate Amputation rate [8 ] PDGF-Becaplermin® 50%, 35%, and 36% of complete healing in 100 μ g/g Becaplermin® gel and placebo and 30 μ g/g Becaplermin® gel, respectively 86 days for 100 μ g/g Becaplermin® gel (decreased time by 32%) NM NM NM N N Y(+) 30% in all groups NM [9 ] rhPDGF-BB gel 48% complete healing in the PDGF group compared with 25% in the placebo group 30 days in the PDGF and 40 days in the placebo group. NM NM NM NM NM NM 26% in PDGF treated versus 46% NM [10 ] Topical PDGF 52% of healing in the test group versus 57% of healing in the control group (not significant) 16 weeks NM Y NM N Y(-) Y(+) NM 3 cases in total [11 ] rhPDGF-BB gel All ulcers in both groups had healed by the end of the study period days 41.8% reduction in healing time ( )NM NM NM NM N Y(+) NM NM [12 ] PDGF Percentage of patients with complete wound contraction was significantly ( ) higher in the PDGF group compared to the other groups 6.75-7.6 weeks Not significant NM NM NM NM N NM NM NM [13 ] PDGF 18 (72%) ulcers had healed in the control group and 15 (60%) in the test group ( ). Three ulcers in the control group showed >75% reduction in size compared to 2 in the test group ( ). 10 weeks NM NM NM NM NM NM NM NM [14 ] PDGF gel A significantly higher ( ) percentage of patients in the rhPDGF-based gel-treated group achieved complete healing 46 days ( ) NM Y NM NM Y(-) NM NM NM [15 ] PDGF The rates of wound closure with TheraGauze and TheraGauze + Becaplermin® were 0.37 and 0.41 cm2/week, respectively ( ) 12 weeks NM Y NM NM NM NM NM N
PDGF: platelet-derived growth factor; Y: yes; N: no; NM: not mentioned.