Journal of Diabetes Research

Research Article

Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes Mellitus

Table 3

Electrophysiologic studies and neurologic examinations of patients by DSPN stage^a with or ≥2.5.


	No DSPN	Minimal DSPN	Subclinical DSPN	DSPN
	No DSPN	Minimal DSPN	Subclinical DSPN	All DSPN	Mild DSPN	Moderate DSPN	Severe DSPN

Total
Patient no.	64	19	18	44	18	14	12
Symptoms of polyneuropathy, (%)	12 (18.8)	4 (21.1)	11 (61.1)	32 (72.7)	12 (66.7)	11 (78.6)	9 (75.0)
Reduction of ankle reflex, (%)	40 (62.5)	19 (100.0)	14 (77.8)	43 (97.7)	17 (94.4)	14 (100.0)	12 (100.0)
Bilateral median neuropathy at wrists, (%)	26 (40.6)	8 (42.1)	13 (72.2)	27 (61.4)	10 (55.6)	11 (78.6)	6 (50.0)
Abnormal thermal test, (%)	6 (9.4)	16 (84.2)	0 (0.0)	40 (90.9)	15 (83.3)	14 (100.0)	11 (91.7)
Abnormal vibration, (%)	0 (0.0)	4 (21.1)	2 (11.1)	24 (54.5)	9 (50.0)	8 (57.1)	7 (58.3)

Patient no.	64	0	18	0	0	0	0
Symptoms of polyneuropathy, (%)	12 (18.8)	—	11 (61.1)	—	—	—	—
Reduction of ankle reflex, (%)	24 (37.5)	—	4 (22.2)	—	—	—	—
Bilateral median neuropathy at wrists, (%)	26 (40.6)	—	13 (72.2)	—	—	—	—
Abnormal thermal test, (%)	6 (9.4)	—	0 (0.0)	—	—	—	—
Abnormal vibration, (%)	0 (0.0)	—	2 (11.1)	—	—	—	—

Patient no.	0	19	0	44	18	14	12
Symptoms of polyneuropathy, (%)	—	4 (21.1)	—	32 (72.7)	12 (66.7)	11 (78.6)	9 (75.0)
Reduction of ankle reflex, (%)	—	0 (0.0)	—	43 (97.7)	17 (94.4)	14 (100)	12 (100)
Bilateral median neuropathy at wrists, (%)	—	8 (42.1)	—	27 (61.4)	10 (55.6)	11 (78.6)	6 (50.0)
Abnormal thermal test, (%)	—	16 (84.2)	—	40 (90.9)	15 (83.3)	14 (100.0)	11 (91.7)
Abnormal vibration, (%)	—	4 (21.1)	—	24 (54.4)	9 (50.0)	8 (57.1)	7 (58.3)

Abbreviations: mMNSI: modified Michigan Neuropathy Screening Instrument; DSPN: distal symmetrical polyneuropathy; DPNP: diabetic peripheral neuropathic pain; NCS: nerve conduction studies. ^aNo DSPN, patients with mMNSI total and NCS severity score 0-1; minimal DSPN, patients with mMNSI total and NCS severity score 0-1; subclinical DSPN, patients with mMNSI total and NCS severity ; DSPN, patients with mMNSI total and NCS severity . Data were compared with DSPN stage, no DSPN using the chi-squared test. , , and indicate significant difference as compared with no DSPN.