Research Article
Association between Thyroid Function and Nonalcoholic Fatty Liver Disease in Euthyroid Type 2 Diabetes Patients
Table 1
Demographic and metabolic characteristics of study subjects by NAFLD status.
| | Characteristics | Non-NAFLD () | NAFLD () | /2/ value | value |
| | General | | | | | | Male (, %) | 143 (64.13%) | 95 (65.52%) | 0.108 | 0.742 | | Age (years) | | | 2.832 | 0.005 | | BMI (kg/m2) | | | -7.233 | <0.001 | | BMR (%) | | | 6.654 | <0.001 | | Duration of diabetes (years) | 8 (3, 14) | 6 (1.75, 10) | -2.043 | 0.041 | | Biochemical markers | | | | | | ALT (IU/L) | 19 (14, 28) | 24 (15.5, 40) | -3.380 | 0.001 | | AST (IU/L) | 19 (16, 25) | 21 (16, 30.5) | -1.949 | 0.051 | | Cr (μmol/L) | | | -1.013 | 0.312 | | eGFR (mL/min/1.73 m2) | | | 0.421 | 0.632 | | Ca2+ (mmol/L) | | | -1.044 | 0.297 | | P (mmol/L) | | | -2.907 | 0.004 | | Glucose metabolism | | | | | | FBG (mmol/L) | | | -0.621 | 0.535 | | FCP (nmol/L) | | | -3.968 | <0.001 | | HbA1c (%) | | | -0.399 | 0.690 | | Fins (pmol/L) | 48.85 (33.62, 81.64) | 66.05 (46.12, 112.62) | -2.983 | 0.003 | | HOMA-IR | 2.75 (1.34, 5.21) | 3.64 (1.59, 6.52) | -1.892 | 0.059 | | Use of hypoglycemic drugs | | | | | | Insulin (, %) | 68 (30.36%) | 39 (26.90%) | 0.512 | 0.474 | | Metformin (, %) | 97 (43.30%) | 79 (54.48%) | 4.410 | 0.036 | | (, %) | 23 (10.27%) | 18 (12.41%) | 0.410 | 0.522 | | (, %) | 102 (45.54%) | 65 (44.83%) | 0.279 | 0.597 | | (, %) | 47 (20.98%) | 27 (18.62%) | 0.306 | 0.580 | | (, %) | 101 (45.09%) | 71 (48.97%) | 0.531 | 0.446 | | Lipid metabolism | | | | | | TG (mmol/L) | 1.40 (1.03, 1.97) | 2.09 (1.59, 3.07) | -7.195 | <0.001 | | TC (mmol/L) | | | -3.814 | <0.001 | | LDL-c (mmol/L) | | | -3.212 | 0.001 | | HDL-c (mmol/L) | | | -0.384 | 0.701 | | Bone metabolism | | | | | | Osteocalcin (ng/mL) | | | 1.422 | 0.156 | | Type I procollagen peptide (ng/mL) | | | 1.068 | 0.289 | | 25-OHD (ng/mL) | | | 0.194 | 0.846 | | β-CrossLaps (pg/mL) | 413.7 (310.9, 664.00) | 393.5 (249.8, 562.7) | -1.462 | 0.144 | | Thyroid metabolism | | | | | | FT3 (pmol/L) | | | -2.969 | 0.003 | | FT4 (pmol/L) | | | 0.297 | 0.767 | | FT3/FT4 ratio | | | -2.401 | 0.017 | | TSH (mIU/L) | | | -1.778 | 0.046 |
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Data are (%), , or median (interquartile range). BMI: body mass index; BMR: basal metabolic rate; ALT: alanine aminotransferase; AST: aspartate transaminase; Cr: creatinine; eGFR: estimated glomerular filtration rate; Ca2+: calcium; P: phosphorus; FBG: fasting blood glucose; Fins: fasting insulin; FCP: fasting c peptide; HbA1c: hemoglobin A1c; HOMA-IR: homeostatic model assessment-insulin resistance; DPP-4i: dipeptidyl peptidase 4 inhibitors; TG: triglycerides; TC: total cholesterol; LDL-c: low-density lipoprotein cholesterol; HDL-c: high-density lipoprotein cholesterol; FT3: free triiodothyronine; TSH: thyroid stimulating hormone; FT4: free thyroxine; NAFLD: nonalcoholic fatty liver disease. |
