Review Article

Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement

Table 1

Overview of renal expression, function, and associated disorders of TRPCs.

TRPCsLocation of expression in kidneyRole in kidneyKidney diseases or injuries associated with TRPC disordersObjects of researchReferences

TRPC1MC; PTEC; TALRegulation of mesangial cell contractility; regulation of Ca2+ influxDiabetic nephropathyHuman; ZDF rats; STZ-induced rats; Ang II-induced human MC[12, 13]
TRPC2A pseudogene and does not form functional channels in human[14]
TRPC3P; CDEC; RFRegulation of Ca2+ influxAutosomal dominant polycystic kidney disease; renal interstitial fibrosisTRPC3−/− mice; UUO rats; CiPTEC cells with siTRPC3; IMCD3 cells treated with pcDNA/TRPC3; RF treated by the pyrazole-derivative TRPC3 blocker pyr3[15, 16]
TRPC4MCStore-operated Ca2+ entryUnknownMouse MC line (CRL-1927) under high-glucose conditions[17]
TRPC5PRegulation of Ca2+ influx; regulation of actin cytoskeleton rearrangement (need to be further investigated)Progressive kidney diseases
Focal segmental glomerulosclerosis
TRPC5-KO mice by LPS injection; mouse podocytes treated by PS, LPS, and Cch[18, 19]
TRPC6P; MC
EC; CDEC
Regulation of Ca2+ influx; regulation of actin cytoskeleton rearrangementFocal segmental glomerulosclerosis; minimal change disease; membranous glomerulonephritis; type-1 diabetes; renal fibrosisHuman; PHN rats; C5b-9-attacked podocytes; HEK293 cells recombined with mouse GFP-TRPC6[20, 21]
TRPC7Unknown

Abbreviations: MC: mesangial cell; PTEC: proximal tubule epithelial cells; TAL: thick ascending limb of the loop of Henle; P: podocytes; CDEC: collecting duct epithelial cells; RF: renal fibroblasts; EC: endothelial cells; ZDF: Zucker diabetic fatty; STZ: streptozotocin; Ang II: angiotensin II; CiPTEC: human conditionally immortalized proximal tubular epithelial cells; IMCD3: mouse inner medullary collecting duct cell line; UUO: unilateral ureteral obstruction; LPS: lipopolysaccharide; PS: protamine sulfate; Cch: carbachol; PHN: the passive Heymann nephritis (PHN) model; HEK: human embryonic kidney.