Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus

Figure 1

Structure of nuclear factor of activated T cells 5 (NFAT) family members. (a) Comparison of structures of NFAT5 and NFAT1-4. Rel homology domain (RHD) exists in NFAT1-5. NFAT5 lacks a calcineurin-binding domain. (b) Specific composition of NFAT5: three transactivation domains (AD): AD1, AD2, and AD3; nuclear export sequence (NES); auxiliary export domain (AED); nuclear localization signal (NLS); dimerization domain (DD).

(a)

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