Associations of KCNQ1 Polymorphisms with the Risk of Type 2 Diabetes Mellitus: An Updated Meta-Analysis with Trial Sequential Analysis
Table 2
Total analysis of seven KCNQ1 gene polymorphisms on T2DM risk.
Variables
a
Cases/controls
Allelic comparison
Homozygote comparison
Heterozygote comparison
Dominant genetic model
Recessive genetic model
OR (95% CI)
b
(%)
c
OR (95% CI)
b
(%)
c
OR (95% CI)
b
(%)
c
OR (95% CI)
b
(%)
c
OR (95% CI)
b
(%)
c
rs2237892
42
50,747/50,023
1.23(1.14, 1.33)
<0.01
88.7
<0.01
1.69(1.45, 1.96)
<0.01
80.2
<0.01
1.40(1.28, 1.54)
<0.01
44.3
<0.01
1.55(1.37, 1.76)
<0.01
71.9
<0.01
1.24(1.12, 1.36)
<0.01
87.7
<0.01
rs2237895
23
42,127/38,276
1.21(1.16, 1.27)
<0.01
74.1
<0.01
1.45(1.32, 1.60)
<0.01
70.7
<0.01
1.23(1.17, 1.29)
<0.01
48.6
0.01
1.28(1.21, 1.36)
<0.01
65.9
<0.01
1.31(1.22, 1.41)
<0.01
56.9
<0.01
rs2237897
12
18,808/18,847
1.27(1.11, 1.46)
<0.01
92.5
<0.01
1.49(1.09, 2.03)
0.01
91.6
<0.01
1.19(0.96, 1.48)
0.11
84.2
<0.01
1.34(1.02, 1.74)
0.03
91.2
<0.01
1.36(1.16, 1.60)
<0.01
88.7
<0.01
rs2283228
10
13,188/12,191
1.25(1.09, 1.42)
<0.01
81.8
<0.01
1.53(1.25, 1.87)
<0.01
50.3
0.03
1.20(1.08, 1.33)
<0.01
0.0
0.90
1.33(1.18, 1.49)
<0.01
10.9
0.34
1.30(1.10, 1.55)
<0.01
83.2
<0.01
rs231362
9
7666/6626
1.16(0.83, 1.61)
0.39
94.7
<0.01
1.51(0.90, 2.53)
0.12
77.1
<0.01
1.22(0.94, 1.58)
0.14
24.5
0.23
1.33(0.90, 1.97)
0.15
65.1
<0.01
1.22(0.82, 1.8)
0.33
94.6
<0.01
rs151290
9
7808/7836
1.14(1.03, 1.27)
0.02
71.2
<0.01
1.35(1.09, 1.66)
<0.01
61.6
0.01
1.20(1.04, 1.38)
0.01
27.5
0.20
1.26(1.08, 1.47)
<0.01
41.1
0.09
1.18(1.02, 1.37)
0.03
73.5
<0.01
rs2074196
5
11,019/11,672
1.31(1.23, 1.39)
<0.01
39.7
0.16
1.75(1.54, 1.99)
<0.01
26.7
0.24
1.33(1.22, 1.46)
<0.01
0.0
0.50
1.51(1.37, 1.66)
<0.01
6.4
0.37
1.37(1.27, 1.49)
<0.01
39.9
0.16
CI: confidence interval; T2DM: type 2 diabetes mellitus. aNumber of comparisons. b value of -test for the significant test. c value of -test for the between-study heterogeneity test.
