Journal of Diabetes Research / 2020 / Article / Tab 2

Research Article

Alterations of Gut Microbiota in Type 2 Diabetes Individuals and the Confounding Effect of Antidiabetic Agents

Table 2

Effect of T2DM and antidiabetic agents on alpha diversity indices and Firmicutes/Bacteroidetes ratio.

VariableHC
()
T2DM
()
valueDiabetic clusters value for HC versus NT
MET
()
GLIM
()
NT
()
value

Alpha diversity indicesObserved species343.29370.330.262400.12399.12311.750.039b0.337
Chao1400.79457.650.054498.27486.74387.960.045b0.742
ACE404.97456.430.058494.79481.64392.840.049b0.731
Shannon5.765.630.523a5.496.095.290.050c0.160a
Simpson0.950.940.369a0.930.960.930.057c0.220a

F/B ratio16.2715.920.117a12.0214.8820.860.852c0.380a

The statistical analysis was performed by two independent-samples -test (parametric), Mann-Whitney testa (nonparametric), one-way ANOVAb (parametric), and Kruskal-Wallis testc (nonparametric). Data presented as mean. A value of less than 0.05 was considered significant. B: Bacteroidetes; F: Firmicutes; GLIM: glimepiride; HC: healthy control; MET: metformin; : number; NT: nontherapeutic; T2DM: type 2 diabetes mellitus.

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