Retinal Neuropathy in IGT Stage of OLETF Rats: Another Characteristic Change of Diabetic Retinopathy

Figure 1

Pathological changes of the retina using H&E (×400). (a) The control group; the inner limiting membrane is clear, and the nerve fibre layer is sparse and regularly arranged; the ganglion cells are neatly arranged in a single layer, and the nuclei are large and round; the inner plexus layer is thicker and has a relatively distinct network structure; the inner granular layer is composed of 3-5 layers of cells; the nuclei are larger and appear slightly darker; the outer plexus layer is distinctly thinner than the inner plexus layer; the outer granular layer is thicker, consisting of 8-10 layers of tightly arranged cells with small, deeply stained nuclei. (b) The NGT group. (c) The IGT group. (d) The DM group. (e) The DKD group.

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