Differential HLA Association of GAD65 and IA2 Autoantibodies in North Indian Type 1 Diabetes Patients
Table 2
Association of the HLA-DRB1 alleles and HLA-DRB1 genotypes with GADA and IA2A in 252 T1D patients.
GADA
IA2A
Positives (%GF) ()
Negatives (%GF) ()
OR (95% CI)
value
Positives (%GF) ()
Negatives (%GF) ()
OR (95% CI)
value
DRB1 allele
01
1 (0.78)
2 (1.61)
0.48 (0.06-3.72)
0.543
0 (0)
3 (1.41)
0 (0-6.88)
1
03
117 (91.41)
82 (66.13)
5.45 (2.67-11.08)
8.55 × 10−7
1.11 × 10−5
32 (80.0)
167 (78.77)
1.08 (0.47-2.45)
1
04
41 (32.03)
32 (25.81)
1.35 (0.79-2.34)
0.342
18 (45.0)
55 (25.94)
2.34 (1.17-4.64)
0.025
0.325
07
16 (12.5)
20 (16.13)
0.74 (0.37-1.5)
0.52
4 (10.0)
32 (15.09)
0.62 (0.22-1.8)
0.55
08
0 (0)
1 (0.81)
0 (0-3.73)
0.987
0 (0)
1 (0.47)
0 (0-20.65)
1
09
7 (5.47)
1 (0.81)
7.12 (1.12-44.84)
0.08
2 (5.0)
6 (2.83)
1.81 (0.4-8.197)
0.821
10
2 (1.56)
8 (6.45)
0.23 (0.05-0.98)
0.096
0 (0)
10 (4.72)
0 (0-1.98)
0.337
11
1 (0.78)
7 (5.65)
0.13 (0.02-0.84)
0.065
1 (2.5)
7 (3.3)
0.75 (0.12-4.87)
1
12
1 (0.78)
3 (2.42)
0.32 (0.045-2.26)
0.592
0 (0)
4 (1.89)
0 (0-5.14)
0.852
13
5 (3.91)
12 (9.68)
0.38 (0.135-1.07)
0.115
3 (7.5)
14 (6.6)
1.15 (0.34-3.93)
1
14
6 (4.69)
12 (9.68)
0.46 (0.17-1.22)
0.196
2 (5.0)
16 (7.55)
0.645 (0.16-2.64)
0.811
15
15 (11.72)
28 (22.58)
0.45 (0.23-0.895)
0.034
0.442
4 (10.0)
39 (18.4)
0.49 (0.17-1.41)
0.29
16
1 (0.78)
4 (3.23)
0.24 (9.03-1.60)
0.348
2 (5.0)
3 (1.41)
3.67 (0.71-19.07)
0.383
DRB1/DRB1 genotype
03/03
38 (29.69)
22 (17.74)
1.96 (1.08-3.54)
0.038
0.228
7 (17.5)
53 (25)
0.64 (0.27-1.5)
0.413
03/04
35 (27.34)
25 (20.16)
1.49 (0.83-2.68)
0.234
15 (37.5)
45 (21.23)
2.23 (1.09-4.54)
0.044
0.264
03/XX
44 (34.37)
35 (28.23)
1.33 (0.78-2.27)
0.360
10 (25)
69 (32.55)
0.69 (0.32-1.48)
0.448
04/04
0 (0)
0 (0)
NA
1
0 (0)
0 (0)
NA
1
04/XX
6 (4.69)
7 (5.65)
0.82 (0.28-2.41)
0.953
3 (7.5)
10 (4.72)
1.64 (0.46-5.83)
0.734
XX/XX
5 (3.91)
35 (28.23)
0.13 (0.04-0.27)
1.28 × 10−7
7.68 × 10−7
5 (12.5)
35 (16.51)
0.72 (0.27-1.92)
0.689
Abbreviations: GF: gene/genotype frequency; CI: confidence interval; OR: odds ratio; : Bonferroni-corrected value; NA: not available; X: an allele other than DRB103 and 04. Statistically significant values are given in italic.