Research Article

Differential HLA Association of GAD65 and IA2 Autoantibodies in North Indian Type 1 Diabetes Patients

Table 2

Association of the HLA-DRB1 alleles and HLA-DRB1 genotypes with GADA and IA2A in 252 T1D patients.

GADAIA2A
Positives (%GF)
()
Negatives (%GF)
()
OR (95% CI) valuePositives (%GF)
()
Negatives (%GF)
()
OR (95% CI) value

DRB1 allele011 (0.78)2 (1.61)0.48 (0.06-3.72)0.5430 (0)3 (1.41)0 (0-6.88)1
03117 (91.41)82 (66.13)5.45 (2.67-11.08)8.55 × 10−71.11 × 10−532 (80.0)167 (78.77)1.08 (0.47-2.45)1
0441 (32.03)32 (25.81)1.35 (0.79-2.34)0.34218 (45.0)55 (25.94)2.34 (1.17-4.64)0.0250.325
0716 (12.5)20 (16.13)0.74 (0.37-1.5)0.524 (10.0)32 (15.09)0.62 (0.22-1.8)0.55
080 (0)1 (0.81)0 (0-3.73)0.9870 (0)1 (0.47)0 (0-20.65)1
097 (5.47)1 (0.81)7.12 (1.12-44.84)0.082 (5.0)6 (2.83)1.81 (0.4-8.197)0.821
102 (1.56)8 (6.45)0.23 (0.05-0.98)0.0960 (0)10 (4.72)0 (0-1.98)0.337
111 (0.78)7 (5.65)0.13 (0.02-0.84)0.0651 (2.5)7 (3.3)0.75 (0.12-4.87)1
121 (0.78)3 (2.42)0.32 (0.045-2.26)0.5920 (0)4 (1.89)0 (0-5.14)0.852
135 (3.91)12 (9.68)0.38 (0.135-1.07)0.1153 (7.5)14 (6.6)1.15 (0.34-3.93)1
146 (4.69)12 (9.68)0.46 (0.17-1.22)0.1962 (5.0)16 (7.55)0.645 (0.16-2.64)0.811
1515 (11.72)28 (22.58)0.45 (0.23-0.895)0.0340.4424 (10.0)39 (18.4)0.49 (0.17-1.41)0.29
161 (0.78)4 (3.23)0.24 (9.03-1.60)0.3482 (5.0)3 (1.41)3.67 (0.71-19.07)0.383

DRB1/DRB1 genotype03/0338 (29.69)22 (17.74)1.96 (1.08-3.54)0.0380.2287 (17.5)53 (25)0.64 (0.27-1.5)0.413
03/0435 (27.34)25 (20.16)1.49 (0.83-2.68)0.23415 (37.5)45 (21.23)2.23 (1.09-4.54)0.0440.264
03/XX44 (34.37)35 (28.23)1.33 (0.78-2.27)0.36010 (25)69 (32.55)0.69 (0.32-1.48)0.448
04/040 (0)0 (0)NA10 (0)0 (0)NA1
04/XX6 (4.69)7 (5.65)0.82 (0.28-2.41)0.9533 (7.5)10 (4.72)1.64 (0.46-5.83)0.734
XX/XX5 (3.91)35 (28.23)0.13 (0.04-0.27)1.28 × 10−77.68 × 10−75 (12.5)35 (16.51)0.72 (0.27-1.92)0.689

Abbreviations: GF: gene/genotype frequency; CI: confidence interval; OR: odds ratio; : Bonferroni-corrected value; NA: not available; X: an allele other than DRB103 and 04. Statistically significant values are given in italic.