Unique Biomarker Characteristics in Gestational Diabetes Mellitus Identified by LC-MS-Based Metabolic Profiling

Table 2

Ten major differential metabolites for future analysis.

ID	Name_des	Formula	Molecular weight	RT (min)	FC	-value	VIP	Up/down
ESI+
Com_962_pos	Eicosapentaenoic acid	C20 H30 O2	302.22	14.10	0.58	4.95E-03	2.28	Down
Com_384_pos	Docosahexaenoic acid	C22 H32 O2	328.24	15.07	1.77	1.62E-06	1.60	Up
Com_2412_pos	Docosapentaenoic acid	C22 H34 O2	330.26	15.24	2.36	6.97E-09	2.23	Up
Com_1075_pos	Arachidonic acid	C20 H32 O2	304.24	15.13	1.50	3.85E-06	1.06	Up
Com_7642_pos	α-Ketoglutaric acid	C5 H6 O5	146.02	1.40	1.18	1.22E-03	0.44	Up
Com_332_pos	Phosphoric acid	H3 O4 P	97.98	1.68	1.65	9.31E-07	1.80	Up
ESI-
Com_108_neg	Citric acid	C6 H8 O7	192.03	1.49	2.11	1.02E-09	3.43	Up
Com_5332_neg	α-Ketoglutaric acid	C5 H6 O5	146.02	1.72	1.78	2.17E-09	2.00	Up
Com_7586_neg	Genistein	C15 H10 O5	270.05	9.61	0.63	6.15E-03	1.17	Down
Com_8251_neg	Daidzein	C15 H10 O4	254.06	9.10	0.52	4.12E-02	1.50	Down
Com_740_neg	Phosphoric acid	H3 O4 P	97.98	1.55	2.33	1.42E-08	4.31	Up
Com_783_neg	2-Furoic acid	C5 H4 O3	112.02	1.50	2.25	1.97E-06	3.15	Up

FC, fold change (GDM case/control). VIP, variable importance in the projection. ESI+, positive ion mode; ESI-, negative ion mode.