Effect of Dipeptidyl Peptidase-4 (DPP-4) Inhibition on Biomarkers of Kidney Injury and Vascular Calcification in Diabetic Kidney Disease: A Randomized Controlled Trial
Table 4
Comparison of mean changes in various parameters from baseline to month 6 between the two groups.
Mean change
Gemigliptin ()
Control ()
95% CI
value
Body weight (kg)
-0.87, 1.75
0.506
Body mass index (kg/m2)
-0.33, 0.65
0.512
Mean arterial blood pressure
-8.89, 1.59
0.171
Hemoglobin (g/dL)
-0.30, 0.28
0.952
Estimated GFR (mL/min/1.73 m2)
-2.29, 4.04
0.587
BUN (mg/dL)
-4.16, 1.10
0.254
Serum creatinine (mg/dL)
-0.16, 0.06
0.389
Fasting plasma glucose (mg/dL)
-38.96, -2.38
0.027
Hemoglobin A1C (%)
-1.05, -0.01
0.048
Serum potassium (mEq/L)
-0.96, 1.44
0.734
Serum magnesium (mg/dL)
-0.01, 0.56
0.057
Serum calcium (mg/dL)
-0.50, 0.02
0.073
Serum phosphate (mg/dL)
-0.29, 0.23
0.800
Serum albumin (g/dL)
-0.03, 0.18
0.152
Urine protein, 24 hours (g/day)
-1.35, 0.35
0.246
Coronary artery calcium score
-42.07, 83.03
0.519
CAVI
-0.22, 0.79
0.265
Serum myeloperoxidase (μg/L)
-543.35, 711.91
0.596
Serum osteopontin (ng/mL)
-543.35, 711.91
0.791
Serum bone alkaline phosphate (μg/L)
-9.16, -2.69
<0.001
Urine NGAL (ng/mg creatinine)
-606.19, -51.43
0.020
Urine Kim (ng/mg creatinine)
-0.08, 0.52
0.156
Urine LFABP (μg/mg creatinine)
-95.30, -26.24
0.001
Data are presented as the and 95% CI. CAVI: cardio-ankle vascular index; LFABP: liver acid-binding protein; NGAL: neutrophil gelatinase-associated lipocalin; Kim-1: kidney injury molecule-1.
