Combination of GLP-1 Receptor Activation and Glucagon Blockage Promotes Pancreatic β-Cell Regeneration In Situ in Type 1 Diabetic Mice

Figure 2

Pancreatic histological analysis of pancreatic α-cell and β-cell mass in T1D and control mice treated with liraglutide, GCGR mAb, or both for four weeks. (a) Representative images of islets immunostained for glucagon (green) and insulin (red). (b–e) Total islet area, α-cell area, β-cell area per pancreatic slice, and the ratio of β-cell area to α-cell area. sections/mouse multiplied by 6 mice/group. Data are expressed as the . Statistical analysis was conducted by ANOVA. vs. control group; ^# vs. STZ group; ^△ vs. GCGR mAb group.

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