Behavior of SD-OCT Detectable Hyperreflective Foci in Diabetic Macular Edema Patients after Therapy with Anti-VEGF Agents and Dexamethasone Implants

Figure 1

Multimodal imaging of a nonvascularized outer retinal layer (ORL) hyperreflective foci (HF). Figure shows the distribution of a HF in a 42-year-old patient with proliferative diabetic retinopathy (PDR) at baseline. Upper panel: HF in the absence of any visible HE on corresponding color fundus photographs (CFP) could be detected. Higher magnification image of the macular area marked with a dashed square. Lower panel: visualization of an outer nuclear layer HF adjacent to a cystoid space on optical coherence tomography (OCT) B-scan with manual segmentation of the vascular slabs of this region visualized as dashed red lines (left). Corresponding en face OCT-angiography (OCTA, right) image of the manually outlined vascular slab confirms, which the HF is not attached to blood vessels. HF border is outlined in yellow and area in mm² is calculated by the device software.