Behavior of SD-OCT Detectable Hyperreflective Foci in Diabetic Macular Edema Patients after Therapy with Anti-VEGF Agents and Dexamethasone Implants

Figure 2

Multimodal imaging of vascularized inner retinal layer (IRL) (IRL) hyperreflective foci (HF) and hard exudates (HE). (a, d) The structural optical coherence tomography (OCT) delineates dot-like HF (a–c) and spot-like HE (d–f) in a 39-year-old patient with mild nonproliferative diabetic retinopathy (NPDR) at baseline. (b, e) B-scan with manual segmentation of the vascular slabs of the region visualized as dashed red line, depicting HF in the inner nuclear layer (INL) and HE in the outer plexiform layer (OPL). (c, f) Corresponding en- face OCT-angiography (OCTA) images of the manually outlined vascular slabs demonstrate HF and HE deposited adjacent to blood vessels. Higher magnification images of the HF and HE are marked by a dash square. Both HF and HE borders are outlined in turquoise, and area in mm² is calculated by the device software.

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