Identification of Flavonoid C-Glycosides as Promising Antidiabetics Targeting Protein Tyrosine Phosphatase 1B

Table 4

Druglikeness properties of orientin and ursolic acid.

Compound	Orientin	Ursolic acid
Molecular weight	448.38 g/mol	456.70 g/mol
Number of rotatable bonds	3	1
No. of H-bond acceptor	11	3
No. of H-bond donors	8	2
TPSA	201.28 Å	57.53 Å
Log	1	3.95
Water solubility (log )	-2.70 (soluble)	-7.23 (poorly soluble)
Bioavailability	0.17	0.85
No. of violations	2 violations: N or and NH or	1 violation,

TPSA: topological polar surface area.