Journal of Diabetes Research

Targeting Oxidative Stress in Diabetic Complications: New Insights


Status
Published

Lead Editor

1The Second Hospital of Jilin University, Changchun, China

2University of Louisville, Louisville, USA

3Baker Heart and Diabetes Institute, Melbourne, Australia

4INRCA Italian National Institute of Health and Science, Ancona, Italy


Targeting Oxidative Stress in Diabetic Complications: New Insights

Description

The dramatic increase in prevalence makes the World Health Organization predict diabetes as the 7th leading cause of death in 2030. Diabetes causes high morbidity and mortality predominantly through its complications. Unfortunately, even though blood glucose and blood pressure are under control, diabetic patients are still at risk of developing diabetic complications, such as cardiovascular disease, nephropathy, retinopathy, neuropathy, skin disorders, and male infertility. Therefore, there is an urgent need to develop more effective therapies to prevent or slow down the progression of diabetic complications.

Oxidative stress plays a critical role in the pathogenesis of diabetic complications. Diabetes-induced overproduction of mitochondrial superoxide leads to a series of detrimental cellular events, including increased formation of advanced glycation end products (AGEs), increased expression of the receptor for AGEs (RAGE), and activation of protein kinase C isoforms, the polyol pathway, and the hexosamine pathway. These effects consequently result in pathological remodeling of the end-organs and their dysfunction. Hence, targeting diabetes-induced oxidative stress has attracted much research interest in recent years.

Approaches have been developed to modulate key factors that control diabetes-induced oxidative stress. Inhibition of NADPH oxidases (NOX) or RAGE blocks the source of reactive oxygen species and thereby alleviates diabetes-induced injury in end-organs. Nuclear factor- (erythroid-derived 2-) like 2 (NRF2) turns on the transcription of multiple antioxidant genes. The increased antioxidants act as scavengers for free radicals. Some of the NRF2 activators have even been tested in clinical trials. In-depth mechanisms are being explored and elucidated, the result of which leads to discovery of novel therapeutics in management of diabetic complications.

The special issue invites investigators to share their original research articles and reviews.

Potential topics include but are not limited to the following:

  • Discovery of oxidative stress-related biomarkers of diabetic complications
  • Novel antioxidant therapeutics in diabetic complications
  • Genetic and epigenetic mechanism in formation or regulation of oxidative stress, as well as regulation of antioxidant activity in diabetic complications
  • Crosstalk between oxidative stress, inflammation, mitochondrial dysfunction, endoplasmic reticulum stress, autophagy, and apoptosis in diabetic complications
  • Role of mitochondria in diabetic complications
  • New insights into assessment and management of diabetic complications, with an emphasis on oxidative stress and antioxidants

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 1909675
  • - Editorial

Targeting Oxidative Stress in Diabetic Complications: New Insights

Hao Wu | Lu Cai | ... | Robertina Giacconi
  • Special Issue
  • - Volume 2018
  • - Article ID 3405695
  • - Research Article

Early Growth Response 1 (Egr1) Is a Transcriptional Activator of NOX4 in Oxidative Stress of Diabetic Kidney Disease

Fang Hu | Meng Xue | ... | Yao-Ming Xue
  • Special Issue
  • - Volume 2017
  • - Article ID 2537216
  • - Research Article

Silymarin Ameliorates Diabetes-Induced Proangiogenic Response in Brain Endothelial Cells through a GSK-3β Inhibition-Induced Reduction of VEGF Release

Ahmed Alhusban | Enaam Alkhazaleh | Tamam El-Elimat
  • Special Issue
  • - Volume 2017
  • - Article ID 1673081
  • - Review Article

The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy

Sonia Sifuentes-Franco | Fermín Paul Pacheco-Moisés | ... | Alejandra Guillermina Miranda-Díaz
  • Special Issue
  • - Volume 2017
  • - Article ID 2070178
  • - Review Article

Antioxidative Effects of Natural Products on Diabetic Cardiomyopathy

Bingdi Yan | Jin Ren | ... | Junling Yang
  • Special Issue
  • - Volume 2017
  • - Article ID 7121827
  • - Review Article

SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models

Yue Cao | Zi Yan | ... | Guixia Wang
  • Special Issue
  • - Volume 2017
  • - Article ID 7680576
  • - Review Article

Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease

Yu Yang | Hui Huang | ... | Jun-kai Duan
  • Special Issue
  • - Volume 2017
  • - Article ID 6785852
  • - Research Article

Aldose Reductase Inhibitor Protects against Hyperglycemic Stress by Activating Nrf2-Dependent Antioxidant Proteins

Kirtikar Shukla | Pabitra Bikash Pal | ... | Kota V. Ramana
Journal of Diabetes Research
 Journal metrics
Acceptance rate32%
Submission to final decision68 days
Acceptance to publication26 days
CiteScore5.500
Impact Factor2.965
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