Journal of Diabetes Research

Genomics and Metabolomics in Obesity and Type 2 Diabetes


Status
Published

Lead Editor

1Medical University of Bialystok, Bialystok, Poland

2CEU San Pablo University, Madrid, Spain


Genomics and Metabolomics in Obesity and Type 2 Diabetes

Description

Problem of obesity concerns all people independently on age, sex, and race and is becoming a burden in modern health care. The most serious clinical problem related to obesity is type 2 diabetes mellitus (T2DM). Although genetic background is important in pathophysiology of obesity and T2DM, less than 10% of the heritability of obesity and/or T2DM can be explained by genetic variants. Consequently, additional information is necessary to study predisposition, evolution, and potential treatment of T2DM and obesity. Metabolomics is another holistic approach which can be used to understand and control biological complexity. Correlational analyses of genetic data with global metabolite measurements (e.g., metabolomics or lipidomics) could further increase our knowledge about relationship between obesity and T2DM. There are also preliminary studies suggesting interactions between obesity genotypes and different response to lifestyle changes, including diet composition and physical activity. Knowledge about these interactions could be extended by addition of metabolomics origin information.

Consequently, the idea of this special issue is to use genomics or genetic variant analysis and metabolomics to study mechanisms of evolution of T2DM or obesity. Also studies on treatment effects and prediction of treatment efficacy are desired. Currently, in case of T2DM and obesity, the effects of treatment strategies which do not use medications (physical activity, diet changes, and weight loss surgeries) on regulation of biological pathways are sought.

Therefore, this special issue will welcome research and review papers devoted to studying type 2 diabetes and obesity by use of genomics, metabolomics, or combination of different OMICS approaches. Research studies can be performed on humans and also on animal models.

Potential topics include, but are not limited to:

  • Searching for novel biomarkers and alteration of biochemical pathways in T2DM and/or obesity
  • Following diabetes and obesity development by use of holistic approaches
  • Evaluation of physical activity as a key component in the prevention of type 2 diabetes by use of OMICS approaches
  • Nutrigenomics in diabetes research
  • Nutrimetabolomics in diabetes research
  • Use of OMICS approaches to study the effects of bariatric surgery in the treatment of type 2 diabetes

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 9415645
  • - Editorial

Genomics and Metabolomics in Obesity and Type 2 Diabetes

Adam Kretowski | Francisco J. Ruperez | Michal Ciborowski
  • Special Issue
  • - Volume 2016
  • - Article ID 6238526
  • - Research Article

Transcriptome Profiles Using Next-Generation Sequencing Reveal Liver Changes in the Early Stage of Diabetes in Tree Shrew (Tupaia belangeri chinensis)

Xiaoyun Wu | Haibo Xu | ... | Bin Liang
  • Special Issue
  • - Volume 2016
  • - Article ID 3467403
  • - Research Article

Conserved Metabolic Changes in Nondiabetic and Type 2 Diabetic Bariatric Surgery Patients: Global Metabolomic Pilot Study

Konrad Sarosiek | Kirk L. Pappan | ... | Hwyda A. Arafat
  • Special Issue
  • - Volume 2016
  • - Article ID 5490258
  • - Review Article

The Stricter the Better? The Relationship between Targeted HbA1c Values and Metabolic Control of Pediatric Type 1 Diabetes Mellitus

Marcin Braun | Bartlomiej Tomasik | ... | Wojciech Mlynarski
  • Special Issue
  • - Volume 2016
  • - Article ID 6314368
  • - Research Article

Genetic Analysis and Follow-Up of 25 Neonatal Diabetes Mellitus Patients in China

Bingyan Cao | Chunxiu Gong | ... | Mei Feng
  • Special Issue
  • - Volume 2016
  • - Article ID 6014631
  • - Research Article

Diabetes Mellitus and Increased Tuberculosis Susceptibility: The Role of Short-Chain Fatty Acids

Ekta Lachmandas | Corina N. A. M. van den Heuvel | ... | Reinout van Crevel
  • Special Issue
  • - Volume 2016
  • - Article ID 5675739
  • - Research Article

CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance

Milton-Omar Guzmán-Ornelas | Marcelo Heron Petri | ... | Rosa-Elena Navarro-Hernández
  • Special Issue
  • - Volume 2016
  • - Article ID 2108909
  • - Research Article

Tyrosine Is Associated with Insulin Resistance in Longitudinal Metabolomic Profiling of Obese Children

Christian Hellmuth | Franca Fabiana Kirchberg | ... | Thomas Reinehr
  • Special Issue
  • - Volume 2016
  • - Article ID 2391592
  • - Research Article

An Investigation into the Antiobesity Effects of Morinda citrifolia L. Leaf Extract in High Fat Diet Induced Obese Rats Using a 1H NMR Metabolomics Approach

Najla Gooda Sahib Jambocus | Nazamid Saari | ... | Azizah Abdul Hamid
Journal of Diabetes Research
 Journal metrics
Acceptance rate32%
Submission to final decision68 days
Acceptance to publication26 days
CiteScore5.500
Impact Factor2.965
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