Journal of Diabetes Research

Insulin Resistance, Type 1 and Type 2 Diabetes, and Related Complications: Current Status and Future Perspective


Publishing date
24 Jan 2014
Status
Published
Submission deadline
06 Sep 2013

1Department of Physiology, College of Medicine, University of Saskatchewan Saskatoon, SK, Canada S7N 5E5

2Division of Cardiovascular Medicine, Department of Medicine, The Henry Ford Heart and Vascular Institute, 2799 West Grand Boulevard, Detroit, MI 48202-2689, USA

3Department of Pharmacology, Center for Integrative Medicine and Center for Molecular Medicine (CIMMBA), University of Florence, Viale Pieraccini 6, 50139 Florence, Italy


Insulin Resistance, Type 1 and Type 2 Diabetes, and Related Complications: Current Status and Future Perspective

Description

The global escalation of obesity and diabetes in developed and developing nations poses a great health challenge. Obesity is one of the major causes of type 2 diabetes. Type 1 diabetes is primarily due to the autoimmune-mediated destruction of pancreatic beta-cell leading to insulin deficiency. This is usually accompanied by alterations in lipid metabolism, enhanced hyperglycemia-mediated oxidative stress, endothelial cell dysfunction, and apoptosis. Similarly, in type 2 diabetes, increased glucotoxicity, lipotoxicity, endoplasmic reticulum-induced stress, and apoptosis lead to the progressive loss of beta-cells. While type 1 diabetes is characterized by the presence of beta-cell autoantibodies, a combination of peripheral insulin resistance and dysfunctional insulin secretion by pancreatic beta-cells is implicated in the pathogenesis of type 2 diabetes. Although insulin resistance has traditionally been associated with type 2 diabetes, mounting evidence indicates that the incidence of insulin resistance in type 1 diabetes is increasing; therefore, novel mechanistic approaches deciphering insulin resistance are needed. Many pathophysiological factors are implicated in insulin resistance. Although the exact natures of these factors are not completely understood, it is widely accepted that oxidative stress, inflammation, and genetic, habitual, environmental and other epigenetic factors play a significant role.

In the past decade, significant strides have been made in elucidating important mechanisms associated with insulin resistance, overt diabetes, and related cardiometabolic diseases. However, more intense research is still needed for a more comprehensive understanding of the pathophysiological profile of insulin resistance in diabetes, especially in situations where diabetes is comorbid with other chronic diseases.

Therefore, this special issue will welcome research and review papers that address a broad range of mechanisms associated with insulin resistance, type 1 diabetes, type 2 diabetes, and related cardiometabolic complications. Potential topics include, but are not limited to:

  • Role of epigenetics in type 1 and type 2 diabetes
  • Novel mechanisms of insulin resistance and dysfunctional glucose metabolism in type 1 and type 2 diabetes
  • Novel prognostic and therapeutic interventions
  • Role of adiposity in insulin signaling and cardiometabolic complications
  • Macrovascular and microvascular complications of diabetic complications including cardiomyopathy, nephropathy, vasculopathy, and neuropathy

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/jdr/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/jdr/drcc/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 276475
  • - Editorial

Insulin Resistance, Type 1 and Type 2 Diabetes, and Related Complications: Current Status and Future Perspective

Joseph Fomusi Ndisang | Sharad Rastogi | Alfredo Vannacci
  • Special Issue
  • - Volume 2014
  • - Article ID 631902
  • - Research Article

Proinflammatory and Prothrombotic State in Subjects with Different Glucose Tolerance Status before Cardiovascular Disease

Irma Isordia-Salas | María Eugenia Galván-Plata | ... | David Santiago-Germán
  • Special Issue
  • - Volume 2014
  • - Article ID 678123
  • - Research Article

The Morphological Features and Mitochondrial Oxidative Stress Mechanism of the Retinal Neurons Apoptosis in Early Diabetic Rats

Xiaoyan Li | Maonian Zhang | Huanfen Zhou
  • Special Issue
  • - Volume 2014
  • - Article ID 804519
  • - Review Article

The Role of MIF in Type 1 and Type 2 Diabetes Mellitus

Yuriko I. Sánchez-Zamora | Miriam Rodriguez-Sosa
  • Special Issue
  • - Volume 2013
  • - Article ID 485082
  • - Review Article

Early Life Factors and Type 2 Diabetes Mellitus

Xinli Jiang | Huijie Ma | ... | Yan Liu
  • Special Issue
  • - Volume 2013
  • - Article ID 527090
  • - Research Article

Treadmill Exercise Preconditioning Attenuates Lung Damage Caused by Systemic Endotoxemia in Type 1 Diabetic Rats

Ching-Hsia Hung | Jann-Inn Tzeng | ... | Jhi-Joung Wang
  • Special Issue
  • - Volume 2013
  • - Article ID 174526
  • - Research Article

Benidipine Protects Kidney through Inhibiting ROCK1 Activity and Reducing the Epithelium-Mesenchymal Transdifferentiation in Type 1 Diabetic Rats

Ganlin Wu | Meirong Xu | ... | Yilan Hu
  • Special Issue
  • - Volume 2013
  • - Article ID 163062
  • - Research Article

Skeletal Muscle-Specific CPT1 Deficiency Elevates Lipotoxic Intermediates but Preserves Insulin Sensitivity

Wanchun Shi | Siping Hu | ... | Wei Qiu
  • Special Issue
  • - Volume 2013
  • - Article ID 651462
  • - Research Article

Correlation of Abdominal Fat Distribution with Different Types of Diabetes in a Chinese Population

Anhui Zhu | Bin Cui | ... | Xiaojin Zhang
  • Special Issue
  • - Volume 2013
  • - Article ID 576916
  • - Clinical Study

The Effects of Glucose Fluctuation on the Severity of Coronary Artery Disease in Type 2 Diabetes Mellitus

Xingguang Zhang | Xiuping Xu | ... | Xiaofeng Lv
Journal of Diabetes Research
 Journal metrics
Acceptance rate31%
Submission to final decision73 days
Acceptance to publication25 days
CiteScore3.020
Impact Factor3.040
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