Journal of Diabetes Research

Molecular Intricacies and the Role of ER Stress in Diabetes


Publishing date
24 Feb 2012
Status
Published
Submission deadline
26 Aug 2011

1Department of Cell and Molecular Biology, Madras Diabetes Research Foundation (MDRF), Chennai 600086, India

2Department of Anatomy and Cell Biology, and Ophthalmology, Wayne State University, School of Medicine, Detroit, MI 48201, USA

3Department of Cell Biology and Physiology, MSC08 4750, 1 University of New Mexico, Albuquerque, NM 87131-0001, USA


Molecular Intricacies and the Role of ER Stress in Diabetes

Description

Diabetes mellitus is a metabolic disease caused by both genetic and environmental factors. The pathogenic mechanism(s) of diabetes are complex, and the complicated networks related to this disease involve distinct signaling pathways. Prolonged activation of the endoplasmic reticulum (ER) stress pathway known as the unfolded protein response (UPR) can lead to cell pathology and subsequent tissue dysfunction. There is now ample evidence that the UPR is chronically activated in many disease states including diabetes. Currently, discovery of potential modulators targeting these pathways has become a potent approach for antidiabetic drug lead compound development.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular intricacies of ER stress and inflammation in diabetes and its vascular complications. We are particularly interested in articles describing the new insights into ER stress pathways by way of genetic, proteomic, biochemical, and molecular biology applications, advances in the identification of ER stress biomarkers in clinical, tissue culture, and animal models, and current concepts in therapeutic measures of diabetes beyond glucose control that would alleviate ER stress, inflammation, and oxidative stress. Potential topics include, but are not limited to:

  • ER stress and UPR pathway
  • ER stress in β-cell dysfunction
  • ER stress and insulin resistance
  • ER stress in diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy
  • ER stress in Type 1 diabetes
  • Mediators of ER stress in atherosclerosis and metabolic syndrome
  • Molecular interactions among ER stress, inflammation, and oxidative stress
  • ER stress and islet amyloid alterations
  • ER stress and autophagy
  • Adaptive and apoptotic responses of ER stress
  • ER stress, exercise and energy balance
  • ER stress pathway and new targets for drug discovery
  • Scope of traditional medicine as ER stress protectors

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jdr/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 958169
  • - Editorial

Molecular Intricacies and the Role of ER Stress in Diabetes

Muthuswamy Balasubramanyam | Lalit P. Singh | Sampathkumar Rangasamy
  • Special Issue
  • - Volume 2012
  • - Article ID 356487
  • - Research Article

Amelioration of Glucolipotoxicity-Induced Endoplasmic Reticulum Stress by a “Chemical Chaperone” in Human THP-1 Monocytes

Raji Lenin | Mariawilliam Sneha Maria | ... | Muthuswamy Balasubramanyam
  • Special Issue
  • - Volume 2012
  • - Article ID 438238
  • - Research Article

TXNIP Links Innate Host Defense Mechanisms to Oxidative Stress and Inflammation in Retinal Muller Glia under Chronic Hyperglycemia: Implications for Diabetic Retinopathy

Takhellambam S. Devi | Icksoo Lee | ... | Lalit P. Singh
  • Special Issue
  • - Volume 2012
  • - Article ID 647914
  • - Research Article

Modulation of Apoptosis Pathways by Oxidative Stress and Autophagy in β Cells

Maorong Wang | Mia Crager | Subbiah Pugazhenthi
  • Special Issue
  • - Volume 2012
  • - Article ID 509437
  • - Review Article

Endoplasmic Reticulum Stress and Insulin Biosynthesis: A Review

Mi-Kyung Kim | Hye-Soon Kim | ... | Keun-Gyu Park
  • Special Issue
  • - Volume 2012
  • - Article ID 187018
  • - Review Article

The Role of Glucosamine-Induced ER Stress in Diabetic Atherogenesis

Daniel R. Beriault | Geoff H. Werstuck
  • Special Issue
  • - Volume 2012
  • - Article ID 238980
  • - Review Article

The Role of Endoplasmic Reticulum Stress in Autoimmune-Mediated Beta-Cell Destruction in Type 1 Diabetes

Jixin Zhong | Xiaoquan Rao | ... | Cong-Yi Wang
  • Special Issue
  • - Volume 2012
  • - Article ID 762565
  • - Research Article

Pentoxifylline Attenuates Methionine- and Choline-Deficient-Diet-Induced Steatohepatitis by Suppressing TNF-α Expression and Endoplasmic Reticulum Stress

Min Kyung Chae | Sang Gyu Park | ... | Byung-Wan Lee
  • Special Issue
  • - Volume 2012
  • - Article ID 589589
  • - Review Article

ER Stress and Apoptosis: A New Mechanism for Retinal Cell Death

Guangjun Jing | Joshua J. Wang | Sarah X. Zhang
  • Special Issue
  • - Volume 2012
  • - Article ID 507986
  • - Review Article

Endoplasmic Reticulum Stress-Related Factors Protect against Diabetic Retinopathy

Wei-Kun Hu | Rong Liu | ... | Bin Li
Journal of Diabetes Research
 Journal metrics
Acceptance rate24%
Submission to final decision91 days
Acceptance to publication36 days
CiteScore3.020
Impact Factor3.040
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