Journal of Diabetes Research

Autonomic Nervous System, Inflammation, and Diabetes: Mechanisms and Possible Interventions


Publishing date
01 Feb 2012
Status
Published
Submission deadline
01 Aug 2011

1Hypertension Unit, Heart Institute (InCor), University of São Paulo Medical School, São Paulo 05403-000, SP, Brazil

2Nephrology Division, Department of Medicine, Federal University of Sao Paulo, Rua Botucatu 740, São Paulo 04023040, SP, Brazil

3Boonshoft School of Medicine, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA

4Department of Clinical Sciences, L. Sacco Hospital, University of Milan,Via GB Grassi 74, 20157 Milano, Italy


Autonomic Nervous System, Inflammation, and Diabetes: Mechanisms and Possible Interventions

Description

Much effort has been focused on understanding the pathophysiology of the complications of diabetes mellitus. Nonetheless, there are still significant gaps in knowledge and evidence that the risk of death and morbidity from cardiovascular disease and stroke is increased in patients with diabetes. It is even thought that diabetes may be considered a cardiovascular disease.

In recent years, autonomic neural and inflammatory mechanisms in the heart and vasculature have emerged as crucial pathophysiological factors in the genesis and progression of diabetes. Abnormal cardiovascular autonomic function and increased markers of heart and vessels inflammation, as well as endothelial dysfunction and reduced vascular distensibility are all associated with worse clinical prognosis. Moreover, there is evidence that sleep patterns changes, both in terms of quantity or quality, are associated with the development of metabolic disturbances, probably through mechanisms medated by ANS. There is a challenge to develop new clinical tools and animal models to better characterize the pathophysiology of cardiovascular impairment in diabetes and to ultimately support to the development of therapeutic interventions.

We invite authors to submit original research and review articles that may contribute to the understanding of the association between the heart and vessels changes observed in diabetes and the autonomic nervous system . We are particularly interested in studies focusing on the autonomic modulation of molecular and inflammatory profile, including changes in renin angiyensin system, the use of heart rate and blood pressure variability as a markers of cardiovascular damage in clinical and animal models, new insights in the pathophysiology-based management of cardiovascular disease in diabetes using exercise, diet, and/or alternative therapies, and effects of sleep disorders on metabolic functions in physiological and pathophysiological conditions. Potential topics include, but are not limited to:

  • Autonomic control of heart rate and blood pressure variability in diabetes
  • Dietary sugars and metabolic models
  • Sleep disturbances and diabetes
  • Therapeutical interventions and their effects on autonomic, inflammatory, and biochemical markers in diabetes
  • Use of different cellular and animal models to understand mechanisms relating ANS and heart and vascular disease in diabetes
  • The renin angiotensin system as a communicative pathway linking changes in the ANS and inflammatory profile in diabetic heart and vessels

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jdr/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 894157
  • - Editorial

Autonomic Nervous System, Inflammation, and Diabetes: Mechanisms and Possible Interventions

M. C. Irigoyen | Dulce Elena Casarini | ... | Nicola Montano
  • Special Issue
  • - Volume 2012
  • - Article ID 494579
  • - Research Article

The Biological Behaviors of Rat Dermal Fibroblasts Can Be Inhibited by High Levels of MMP9

Sheng-Neng Xue | Juan Lei | ... | Li Yan
  • Special Issue
  • - Volume 2012
  • - Article ID 657103
  • - Review Article

The Influence of Autonomic Dysfunction Associated with Aging and Type 2 Diabetes on Daily Life Activities

Jerrold Petrofsky | Lee Berk | Hani Al-Nakhli
  • Special Issue
  • - Volume 2012
  • - Article ID 750286
  • - Clinical Study

Inflammation, Diabetes, and Chronic Kidney Disease: Role of Aerobic Capacity

Flávio Gobbis Shiraishi | Fernanda Stringuetta Belik | ... | Roberto Jorge da Silva Franco
  • Special Issue
  • - Volume 2012
  • - Article ID 459087
  • - Research Article

Effects of Restricted Fructose Access on Body Weight and Blood Pressure Circadian Rhythms

Danielle Senador | Swapnil Shewale | ... | Mariana Morris
  • Special Issue
  • - Volume 2012
  • - Article ID 615835
  • - Clinical Study

Links between Metabolic Syndrome and Cardiovascular Autonomic Dysfunction

G. Garruti | F. Giampetruzzi | ... | F. Giorgino
  • Special Issue
  • - Volume 2012
  • - Article ID 309231
  • - Research Article

The Effects of Green Tea Consumption on Cardiometabolic Alterations Induced by Experimental Diabetes

Patricia Fiorino | Fabiana Sant'Anna Evangelista | ... | Vera Farah
  • Special Issue
  • - Volume 2012
  • - Article ID 108680
  • - Research Article

Dynamic Aerobic Exercise Induces Baroreflex Improvement in Diabetic Rats

Luciana Jorge | Demilto Y. da Pureza | ... | Kátia De Angelis
  • Special Issue
  • - Volume 2012
  • - Article ID 878760
  • - Research Article

Cardiac Autonomic Imbalance in Newly Diagnosed and Established Diabetes Is Associated with Markers of Adipose Tissue Inflammation

David C. Lieb | Henri K. Parson | ... | Aaron I. Vinik
  • Special Issue
  • - Volume 2012
  • - Article ID 820989
  • - Research Article

Regulation of LYRM1 Gene Expression by Free Fatty Acids, Adipokines, and Rosiglitazone in 3T3-L1 Adipocytes

Min Zhang | Hai-Ming Zhao | ... | Xi-Rong Guo
Journal of Diabetes Research
 Journal metrics
Acceptance rate32%
Submission to final decision68 days
Acceptance to publication26 days
CiteScore5.500
Impact Factor2.965
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