Journal of Diabetes Research

Diabetic Microvascular Complications: Novel Risk Factors, Biomarkers, and Risk Prediction Models


Status
Published

1Singapore Eye Research Institute, Singapore

2National University of Singapore, Singapore

3Sun Yat-sen University, Guangzhou, China

4Centre for Public Health, Belfast, UK

5West Virginia University, Morgantown, USA


Diabetic Microvascular Complications: Novel Risk Factors, Biomarkers, and Risk Prediction Models

Description

The prevalence of diabetes mellitus is increasing worldwide and is expected to affect 300 million people worldwide by 2025. Persons with diabetes are at increased risk of developing microvascular complications such as diabetic retinopathy (DR), a leading cause of blindness, diabetic nephropathy (DN), a leading cause of renal failure, and diabetic peripheral neuropathy (DPN), a leading cause of diabetic foot disorders and lower limb amputations. As many older persons with diabetes are living longer, the prevalence of these microvascular complications is also on the rise despite improvements in control of glycemia, blood pressure, and lipid levels. Given that these microvascular complications are largely preventable, it is important to identify novel risk factors or biomarkers associated with early detection of onset/progression of DR, DN, and DPN. Several biomarkers representing underlying pathogenic mechanisms including inflammation, endothelial dysfunction, oxidative stress, hemostasis and microangiopathy, biomarkers at the level of proteome and metabolome, and biomarkers representing end-organ damage such as retinal microvascular parameters have been evaluated for predicting the risk of DR, DN, and DPN. Similarly, several novel risk factors such as lower 25 (OH) D levels and presence of one microvascular complication (e.g., DR predicting DN or DPN predicting DN/DR) have also been investigated for predicting the risk of these conditions.

We invite investigators to contribute original research articles as well as review articles that seek to identify novel risk factors and/or biomarkers for predicting the onset/progression of DR, DN, and DPN and correlations between these conditions.

Potential topics include, but are not limited to:

  • Novel biomarkers and/or risk factors associated with DR
  • Novel biomarkers and/or risk factors associated with DN
  • Novel biomarkers and/or risk factors associated with DPN
  • Relationship between concomitant diabetic microvascular complications
  • Predictive models for identifying diabetic patients at risk of progression to DR/DN/DPN or for stratification of risk
  • Health services and outcomes research related to risk factors associated with DR/DN/DPN

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 2172106
  • - Editorial

Diabetic Microvascular Complications: Novel Risk Factors, Biomarkers, and Risk Prediction Models

Gareth J. McKay | Boon Wee Teo | ... | Charumathi Sabanayagam
  • Special Issue
  • - Volume 2016
  • - Article ID 7684038
  • - Research Article

Bioinformatic Evaluation of Transcriptional Regulation of WNT Pathway Genes with reference to Diabetic Nephropathy

Gareth J. McKay | David H. Kavanagh | ... | Alexander P. Maxwell
  • Special Issue
  • - Volume 2016
  • - Article ID 6571976
  • - Research Article

Development of Diagnostic Biomarkers for Detecting Diabetic Retinopathy at Early Stages Using Quantitative Proteomics

Jonghwa Jin | Hophil Min | ... | Youngsoo Kim
  • Special Issue
  • - Volume 2015
  • - Article ID 404280
  • - Research Article

Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes

Chee Wai Wong | Boon Wee Teo | ... | Charumathi Sabanayagam
  • Special Issue
  • - Volume 2015
  • - Article ID 351601
  • - Research Article

A Cross-Sectional Study Demonstrating Increased Serum Amyloid A Related Inflammation in High-Density Lipoproteins from Subjects with Type 1 Diabetes Mellitus and How This Association Was Augmented by Poor Glycaemic Control

Jane McEneny | Jane-Ann Daniels | ... | James Gibney
  • Special Issue
  • - Volume 2015
  • - Article ID 694107
  • - Research Article

Linkage Analysis of Genomic Regions Contributing to the Expression of Type 1 Diabetes Microvascular Complications and Interaction with HLA

Ettie M. Lipner | Yaron Tomer | ... | David A. Greenberg
  • Special Issue
  • - Volume 2015
  • - Article ID 231570
  • - Research Article

Regular Chinese Green Tea Consumption Is Protective for Diabetic Retinopathy: A Clinic-Based Case-Control Study

Qinghua Ma | Dandan Chen | ... | Chen-Wei Pan
Journal of Diabetes Research
 Journal metrics
Acceptance rate32%
Submission to final decision68 days
Acceptance to publication26 days
CiteScore5.500
Impact Factor2.965
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