Journal of Diabetes Research

Insulin Resistance, Type 1 and Type 2 Diabetes, and Related Complications 2017


Status
Published

1University of Saskatchewan, Saskatoon, Canada

2The Henry Ford Heart and Vascular Institute, Detroit, USA

3University of Florence, Florence, Italy


Insulin Resistance, Type 1 and Type 2 Diabetes, and Related Complications 2017

Description

The global escalation of obesity and diabetes in developed and developing nations poses a great health challenge. Obesity is one of the major causes of type 2 diabetes. Type 1 diabetes is primarily due to the autoimmune-mediated destruction of pancreatic beta-cell leading to insulin deficiency. This is usually accompanied by alterations in lipid metabolism, enhanced hyperglycemia-mediated oxidative stress, endothelial cell dysfunction, and apoptosis. Similarly, in type 2 diabetes, increased glucotoxicity, lipotoxicity, endoplasmic reticulum-induced stress, and apoptosis lead to the progressive loss of beta-cells. While type 1 diabetes is characterized by the presence of beta-cell autoantibodies, a combination of peripheral insulin resistance and dysfunctional insulin secretion by pancreatic beta-cells is implicated in the pathogenesis of type 2 diabetes. Although insulin resistance has traditionally been associated with type 2 diabetes, mounting evidence indicates that the incidence of insulin resistance in type 1 diabetes is increasing; therefore, novel mechanistic approaches deciphering insulin resistance are needed. Many pathophysiological factors are implicated in insulin resistance. Although the exact natures of these factors are not completely understood, it is widely accepted that oxidative stress, inflammation, and genetic, habitual, environmental, and other epigenetic factors play a significant role.

In the past decade, significant strides have been made in elucidating important mechanisms associated with insulin resistance, overt diabetes, and related cardiometabolic diseases. However, more intense research is still needed for a more comprehensive understanding of the pathophysiological profile of insulin resistance in diabetes, especially in situations where diabetes is comorbid with other chronic diseases.

Therefore, this special issue will welcome research and review papers that address a broad range of mechanisms associated with insulin resistance, type 1 diabetes, type 2 diabetes, and related cardiometabolic complications.

Potential topics include but are not limited to the following:

  • Role of epigenetics in type 1 and type 2 diabetes
  • Novel mechanisms of insulin resistance and dysfunctional glucose metabolism in type 1 and type 2 diabetes
  • Novel prognostic and therapeutic interventions
  • Role of adiposity in insulin signaling and cardiometabolic complications
  • Macrovascular and microvascular complications of diabetic complications including cardiomyopathy, nephropathy, vasculopathy, and neuropathy

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 1478294
  • - Editorial

Insulin Resistance, Type 1 and Type 2 Diabetes, and Related Complications 2017

Joseph Fomusi Ndisang | Alfredo Vannacci | Sharad Rastogi
  • Special Issue
  • - Volume 2017
  • - Article ID 6915310
  • - Research Article

Effects of Renal Denervation on Insulin Sensitivity and Inflammatory Markers in Nondiabetic Patients with Treatment-Resistant Hypertension

Ulla Kampmann | Ole N. Mathiassen | ... | Per L. Poulsen
  • Special Issue
  • - Volume 2017
  • - Article ID 1018796
  • - Research Article

Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic Subjects

Flávia De C. Cartolano | Gabriela D. Dias | ... | Nágila R. T. Damasceno
  • Special Issue
  • - Volume 2017
  • - Article ID 4826724
  • - Review Article

The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus

Joshua A. David | William J. Rifkin | ... | Daniel J. Ceradini
  • Special Issue
  • - Volume 2017
  • - Article ID 8103904
  • - Research Article

Gene Expression Profiling Identifies Downregulation of the Neurotrophin-MAPK Signaling Pathway in Female Diabetic Peripheral Neuropathy Patients

Lin Luo | Wen-Hua Zhou | ... | Lin-Dan Ji
  • Special Issue
  • - Volume 2017
  • - Article ID 5612049
  • - Research Article

Decreased Cardiovascular Risk after Roux-en-Y Gastric Bypass Surgery in Chinese Diabetic Patients with Obesity

Xue Zhao | Wenyan Duan | ... | Guixia Wang
  • Special Issue
  • - Volume 2017
  • - Article ID 5139750
  • - Research Article

High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report

Tsuyoshi Okura | Etsuko Ueta | ... | Kazuhiro Yamamoto
  • Special Issue
  • - Volume 2017
  • - Article ID 2654520
  • - Research Article

Liver-Specific Overexpression of Gamma-Glutamyltransferase Ameliorates Insulin Sensitivity of Male C57BL/6 Mice

Yang Long | Dan Jia | ... | Tao Chen
  • Special Issue
  • - Volume 2017
  • - Article ID 8248725
  • - Research Article

Exercise Metabolism in Nonobese Patients with Type 2 Diabetes Following the Acute Restoration of Normoglycaemia

Christopher J. Gaffney | Peter Mansell | ... | Kostas Tsintzas
  • Special Issue
  • - Volume 2017
  • - Article ID 1567467
  • - Research Article

Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese

Chikako Fujii | Toshihide Kawai | ... | Hiroshi Itoh
Journal of Diabetes Research
 Journal metrics
Acceptance rate32%
Submission to final decision68 days
Acceptance to publication26 days
CiteScore5.500
Impact Factor2.965
 Submit