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Renocardiac Axis in Diabetes: Mechanistic Insights and Therapeutic Strategies

Call for Papers

Diabetic nephropathy is a worldwide public health problem; it is the leading cause of end-stage renal disease (ESRD) and is associated with increased mortality from cardiovascular complications in diabetic patients. The tight interactions between kidney and heart are becoming increasingly evident, and a large number of diabetic patients die due to cardiovascular disease before they develop ESRD. Several factors have been implicated in the pathogenesis of diabetic kidney injury and cardiovascular dysfunction. However, current treatment relies on optimization of blood pressure, glucose, and lipid abnormalities associated with insulin resistance or diabetes. This approach is insufficient to prevent the progression to kidney and heart failure. Given the importance of diabetic nephropathy as a major risk factor for macrovascular complications and the emergence of new antidiabetic drugs (e.g., incretin mimetics, sodium glucose cotransporter 2 inhibitors), it is essential to understand how this disease progresses and how the vascular disease is involved.

In this special issue, we invite researchers to submit original research articles as well as review articles focusing on the molecular mechanisms of renal and cardiovascular complications in diabetic patients. Contributions showing original therapeutic opportunities or strategies for reducing renocardiac syndrome are also encouraged.

Potential topics include but are not limited to the following:

  • Cellular and molecular mechanism of diabetic nephropathy
  • Pathogenesis of endothelial dysfunction and atherosclerosis in patients with diabetes
  • Risk factors among patients with diabetic nephropathy that contribute to cardiovascular disease (e.g., obesity, insulin resistance, volume overload, anemia, and uremia)
  • Roles of activated renin-angiotensin-aldosterone system (RAAS), inflammation, oxidative stress, signaling cascade, and mitochondrial homeostasis in pathophysiology of renocardiac syndrome in diabetes
  • Novel therapeutic approaches to diabetic nephropathy, cardiovascular complications, and to the interaction between these two

Authors can submit their manuscripts through the Manuscript Tracking System at

Submission DeadlineFriday, 25 May 2018
Publication DateOctober 2018

Papers are published upon acceptance, regardless of the Special Issue publication date.

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