Animal Models of Diabetes and its Associated Complications
1Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal (Westville Campus), Durban 4000, South Africa
2Department of Endocrinology and Metabolism, Kanazawa Medical University, Kahoku-gun, Ishikawa 920-0293, Japan
3Laboratory of Developmental Physiology, University of Paris, Paris, France
Animal Models of Diabetes and its Associated Complications
Description
Diabetes is a major threat to global public health. According to the latest data from the International Diabetes Federation (IDF), at least 366 million people are living with diabetes and this number is projected to be 552 million by 2030. At least 50% of the people with diabetes have suffered from one or two major diabetic complications such as diabetic cardiomyopathy, nephropathy, neuropathy, retinopathy, and diabetic foot diseases. Development of an authentic model for each type of diabetes and its associated complications, which exactly mimics the human pathogenesis, is very crucial not only for a better understanding of the core causes of the diseases but also for the development and routine pharmacological screening of novel antidiabetic drugs. A number of genetic and nongenetic animal models of the different types of diabetes and their associated complications have been developed in the last three decades but none of them are without limitations.
We invite investigators to contribute original research and review articles in the area of the development of a better and more authentic animal model of the different types of diabetes and their associated complications, which may be more suitable to understand the major causes of the disease and its complications and may be easier to induce, widely available, cost effective as well as will be suitable for the development and routine pharmacological screening of antidiabetic drugs, functional and medicinal foods, and natural products. Potential topics include, but are not limited to:
- Genetic or spontaneously induced animal models of type 1 or type 2 diabetes
- Nongenetic or experimentally induced animal models of type 1 or type 2 diabetes
- Animal models of gestational diabetes
- Animal models of diabetic complications such as:
- Diabetic cardiomyopathy
- Diabetic retinopathy
- Diabetic nephropathy
- Diabetic retinopathy and
- Diabetic foot diseases
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