Table of Contents
Journal of Dental Surgery
Volume 2014, Article ID 158709, 7 pages
Research Article

Epidermal Growth Factor Receptor Protein: A Biological Marker for Oral Precancer and Cancer

1Department of Oral Pathology & Microbiology, Chandra Dental College Hospital, Safedabad, Barabanki 225001, India
2Department of Oral Pathology & Microbiology, Career Post Graduate Institute of Dental Sciences and Hospital, Lucknow 226001, India
3Department of Oral Pathology & Microbiology, Kothiwal Dental College & Research Centre, Moradabad 244001, India
4Oral & Maxillofacial Surgery, Kothiwal Dental College & Research Centre, Moradabad 244001, India
5Department of Oral Pathology & Microbiology, Institute of Dental Sciences, Bareilly 243001, India
6Department of Oral Pathology & Microbiology, Haldia Institute of Dental Sciences and Research, Uttar Pradesh 721645, India

Received 15 October 2013; Revised 26 November 2013; Accepted 9 December 2013; Published 9 February 2014

Academic Editor: Kenji Yamagata

Copyright © 2014 Ashish Mahendra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The aim of the present paper was to study the expression and overexpression of EGFR in oral leukoplakia and cancer and at the same time assess the expression of EGFR in various histological grades of oral leukoplakia and OSCC in the Indian subcontinent. Methods. The study was conducted with routine H&E and IHC staining on 40 archival tissues. Results. Positive EGFR staining was present in all the cases 100% (30/30) out of which 7 (46.7%) cases of OSCC showed >75% EGFR expression and 8 (53.3%) cases of oral leukoplakia showed 25% EGFR expression. A statistically significant correlation was found in OSCC, OL and controls. Conclusions. EGFR may represent a promising target for novel molecular cancer therapies. EGFR expression levels in the premalignant lesion appear to be a sensitive factor in predicting the neoplastic potential of dysplastic tissues. This suggests that EGFR may serve as a biological marker to identify high-risk subgroups and guide prophylactic therapy.