Epidermal Growth Factor Receptor Protein: A Biological Marker for Oral Precancer and Cancer
Table 1
(a) Characteristics of EGFR expression in oral squamous cell carcinoma, oral leukoplakia, and controls. (b) Multiple comparisons between the three study groups.
(a)
Characteristics
Oral squamous cell carcinoma (Group I)
Oral leukoplakia (Group II)
Controls (Group III)
Sex
Male
11 (73.3%)
10 (66.7%)
6 (60%)
Female
4 (26.7%)
5 (33.3%)
4 (40%)
Age
≤40 yrs
2 (13.3%)
10 (66.7%)
4 (40%)
>40 yrs
13 (86.7%)
5 (33.3%)
6 (60%)
Tobacco use
No
0 (0%)
5 (33.3%)
8 (80%)
Yes
15 (100%)
10 (66.7%)
2 (20%)
Duration of tobacco use
No history
0 (0%)
5 (33.3%)
8 (80%)
Up to 10 yrs
4 (26.7%)
6 (40%)
2 (20%)
11–20 yrs
8 (53.3%)
3 (20%)
0 (0%)
21–30 yrs
3 (20%)
1 (6.7%)
0 (0%)
Histological Diagnosis
WD 5 (33.3%)
Mild 5 (33.3%)
MD 5 (33.3%)
Moderate 5 (33.3%)
PD 5 (33.3%)
Severe 5 (33.3%)
EGFR expression
No
0 (0%)
0 (0%)
9 (90%)
Yes
15 (100%)
15 (100%)
1 (10%)
Extent of EGFR expression
0–25%
3 (20%)
8 (53.3%)
10 (100%)
26–50%
0 (0%)
6 (40%)
0 (0%)
51–75%
5 (33.3%)
1 (6.7%)
0 (0%)
>75%
7 (46.7%)
0 (0%)
0 (0%)
Mean ± SD
Range
15–95
10–58
0–10
; .
(b)
Serial number
Comparison
1
Group I (OSCC) versus Group II (oral leukoplakia)
3.412
<0.001
2
Group I (OSCC) versus Group III (control)
2.244
0.015
3
Group II (oral leukoplakia) versus Group III (control)
