Review Article
Toxicity of Xanthene Food Dyes by Inhibition of Human Drug-Metabolizing
Enzymes in a Noncompetitive Manner
Table 1
Summary of IC50 values of CYP3A4, UGT1A6, and P-glycoprotein inhibition by chemical food dyes.
| | Dye | | I value (M) | | | CYP3A4 | UGT1A6 | P-glycoprotein |
| | Phloxine (PL) | 5.6 | 40 | 24.5 | | Rose Bengal (RB) | 21.2 | 15 | 11.7 | | Erythrosine B (ET) | 7.9 | 50 | 15.6 | | Acid red (AR) | 10.3 | 1000 | 1000 | | Amaranth (AM) | 1000 | 1000 | 1000 | | Allura red (AL) | 1000 | 1000 | 1000 | | New coccine (NC) | 1000 | 1000 | 1000 | | Tartrazine (TT) | 1000 | 1000 | 1000 | | Sunset yellow FCF (SY) | 1000 | 1000 | 1000 | | Brilliant blue FCF (BB) | 1000 | 1000 | 1000 | | Indigo carmine (ID) | 1000 | 1000 | 1000 |
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