Table 2: Summary of mechanisms suggested for main obesogen chemicals.

MechanismActing byChemicals

Metabolic sensorsPPAR, RXR, TRTBT, TPT, PFCs, phthalate
Sex steroid dysregulationsCYP19, ER, ARTBT, TPT, phthalate, BPA, alkylphenol, phytoestrogen, DES
Central integration of energy balance PH, HPA, EC, NETBT, TPT, phthalate, BPA, alkylphenol, phytoestrogen, SSRI, typical antidepressant, atypical antipsychotic
Metabolic pointGR signaling(11_HSD), HPTTBT, TPT, PBDEs, Dithiocarbamates, Glycyrrhetinic acid,TZD

TBT: tributyltin; TPT: triphenyltin; BPA: bisphenol A; PFCs: perfluoroalkyl compounds; PBDEs: polybrominated diphenyl ethers; DES: diethylstilbestrol; SSRI: selective serotoninreuptake inhibitor; TZD: thiazolidinediones; NE: neuroendocrine effects; PH: peptidergic hormones; EC: endocannabinoid; HPT: hypothalamus-pituitary-thyroid; HPA: hypothalamus-pituitary-adrenal.; TR: thyroid hormone receptor; PPAR: peroxisome proliferator activated receptors; RXR: 9-cis retinoic acid receptor; ER: estrogen receptors; AR: androgen receptors.