Assessing Cancer Risk Associated with Aquatic Polycyclic Aromatic Hydrocarbon Pollution Reveals Dietary Routes of Exposure and Vulnerable Populations

Table 1

Monte Carlo simulation variables and distributions for cancer risk assessment due to oral and dermal sediment exposure at the AWI Superfund site.

Parameter	Symbol	Units	Distribution-AT	Distribution-CT	Distribution-AR	Distribution-CR
Concentration of 7 PAHs in sediment	CS	mg/kg	0.283	0.283	0.283	0.283
Average time-Cancer	AT	days	25550	25550	25550	25550
Age-dependent adjustment factor	ADAF	Unitless	1	10	1	10
Conversion factor	CF	Unitless	0.000001	0.000001	0.000001	0.000001
Body weight	BW	kg	80 ± 20	15 ± 3.75	80 ± 20	15 ± 3.75
Oral exposure
Benzo(a)anthracene cancer slope factor	BaA	mg/kg-day	7.30E − 01	7.30E − 01	7.30E − 01	7.30E − 01
Benzo(a)pyrene cancer slope factor	BaP	mg/kg-day	7.30E + 00	7.30E + 00	7.30E + 00	7.30E + 00
Benzo(b)fluoranthene cancer slope factor	BbF	mg/kg-day	7.30E − 01	7.30E − 01	7.30E − 01	7.30E − 01
Benzo(k)fluoranthene cancer slope factor	BkF	mg/kg-day	7.30E − 02	7.30E − 02	7.30E − 02	7.30E − 02
Chrysene cancer slope factor	Chr	mg/kg-day	7.30E − 03	7.30E − 03	7.30E − 03	7.30E − 03
Dibenz(a,h)anthracene cancer slope factor	Dib	mg/kg-day	7.30E + 00	7.30E + 00	7.30E + 00	7.30E + 00
Indeno(1,2,3-c,d)pyrene cancer slope factor	Ind	mg/kg-day	7.30E − 01	7.30E − 01	7.30E − 01	7.30E − 01
Exposure frequency	EF	days/year	40 ± 10	52 ± 13	32 ± 8	48 ± 12
Exposure duration	ED	years	20 ± 5	6 ± 1.5	20 ± 5	6 ± 1.5
Ingestion rate-sediment	IR-S	mg/day	20 ± 5	50 ± 12.5	20 ± 5	50 ± 12.5
Dermal exposure
Benzo(a)anthracene cancer slope factor	BaA	mg/kg-day	2.50E + 00	2.50E + 00	2.50E + 00	2.50E + 00
Benzo(a)pyrene cancer slope factor	BaP	mg/kg-day	2.50E + 01	2.50E + 01	2.50E + 01	2.50E + 01
Benzo(b)fluoranthene cancer slope factor	BbF	mg/kg-day	2.50E + 00	2.50E + 00	2.50E + 00	2.50E + 00
Benzo(k)fluoranthene cancer slope factor	BkF	mg/kg-day	2.50E − 01	2.50E − 01	2.50E − 01	2.50E − 01
Chrysene cancer slope factor	Chr	mg/kg-day	2.50E − 02	2.50E − 02	2.50E − 02	2.50E − 02
Dibenz(a,h)anthracene cancer slope factor	Dib	mg/kg-day	2.50E + 01	2.50E + 01	2.50E + 01	2.50E + 01
Indeno(1,2,3-c,d)pyrene cancer slope factor	Ind	mg/kg-day	2.50E + 00	2.50E + 00	2.50E + 00	2.50E + 00
Exposure frequency	EF	days/year	40 ± 10	52 ± 13	32 ± 8	48 ± 12
Exposure duration	ED	years	20 ± 5	6 ± 1.5	20 ± 5	6 ± 1.5
Soil to skin adherence factor	AF	mg/cm^2-day	0.07 ± 0.0175	0.2 ± 0.05	0.2 ± 0.05	0.07 ± 0.0175
Dermal absorption fraction	ABSd	Unitless	0.13	0.13	0.13	0.13
Skin surface area available for contact	SA	cm^2	6032 ± 1508	2373 ± 593.25	6032 ± 1508	2373 ± 593.25

AT = adult trespasser; CT = child trespasser; AR = adult recreational user; CR = child recreational user.