Research Article

Estimating Typhoid Fever Risk Associated with Lack of Access to Safe Water: A Systematic Literature Review

Table 4

Other significant risk factors for typhoid fever identified in reviewed papers.

Study SiteRisk CategoryExposure factorAOR (95% CI; p-value if any)Source

Dushanbe, TajikistanWater storage and handlingUnboiled water6.5 (3.0 – 24.0; p < 0.05) [11]
Food handling and consumptionEating food obtained from street vendor2.9 (1.4 – 7.2; p < 0.05)

Kathmandu, NepalSocio-economicHousehold monthly income < US$1252.55 (1.1 – 6.0; p < 0.05) [12]
Hygiene & sanitaryHousehold latrine8.52 (1.8 – 40.1; p < 0.05)
Water storage & handlingWater stored after collection3.09 (1.2 – 8.1; p < 0.05)
Eaten street food < 2 weeks2.34 (1.4 – 4.0; p < 0.05)

West Bengal, IndiaFood handling and consumptionFood from sweet shop6.2 (2.4 – 2.2) [19]
Socio-economicMonthly family income < 15006 (1.3 – 26.8)
INR (eqvt. US$ 34)
Living conditionHousehold > 4 members4.2 (1.7 – 11.1)
Living conditionAnyone ill in neighborhood2.5 (1.2–5.2)
Food handling and consumptionEating of Paratha (flatbread in layers)2.1 (0.87–5.3)

Neapolitan Area, ItalyFood handling and consumptionAny raw Shellfish13.3 (5.5 – 32.8; p < 0.05) [14]
Food handling and consumptionRaw Oysters9.3 (1.7 – 67.3; p < 0.05)
Food handling and consumptionRaw Mussels8.9 (3.9 – 21.1; p < 0.05)
Food handling and consumptionRaw Hen Clams8.1 (2.8 – 23.7; p < 0.05)
Food handling and consumptionRaw Sea Truffles6.4 (1.4 – 32.9; p < 0.05)

Madaya Township, MyanmarLiving conditionContact with typhoid patient10.9 (2.0-79.7) [15]

Son La Province, Northern VietnamSocio-economicBeing uneducated2.0 (1.0 – 3.7; p = 0.03) [16]
Living conditionContact with typhoid patient3.3 (1.7 – 6.2; p < 0.05)

Samarkand Oblast, UzbekistanSocio-economicStudent as primary occupation4.0 (1.4 – 11.3; p < 0.05) [18]
Taken antimicrobials in 2 weeks before illness onset12.2 (4.0 – 37.0; p < 0.05)

Darjeeling, West Bengal, IndiaFood handling and consumptionEating raw cabbage2.8 (1.7-4.8) [19]
Water storage & handlingScooping water from a container with a cup2.5 (1.3-4.7)
Food handling and consumptionConsumption of butter2.3 (1.3-4.1)
Food handling and consumptionConsumption of Yoghurt2.3 (1.4-3.7)
Food handling and consumptionEating unwashed grapes2.2 (1.3-4.0)
Food handling and consumptionEating raw onion2.1 (1.2-3.9)
Food handling and consumptionEating raw carrot2.1 (1.2-3.9)

Dhaka slum, Kamalapur, BangladeshWater storage & handlingConsumption of foul-smelling water7.4 (2.1 – 25.4; p = 0.002) [20]
Food handling and consumptionConsumption of unwashed Papaya5.2 (1.2 – 22.2; p = 0.03)

Karachi, PakistanTaken antimicrobials in 2 weeks prior to illness3.0 (1.4 – 6.5) [21]
Food handling and consumptionEating at restaurant between July and August2.7 (1.1-6.6; p = 0.01)
Food handling and consumptionEating at road side cabin between July and August2.4 (1.0-5.6; p = 0.03)
Food handling and consumptionEating out >1 per week between July and August2.3 (1.0-5.2; p = 0.02)
Food handling and consumptionEating ice cream1.7 (1.0-3.1; p = 0.03)
Food handling and consumptionEating a commercial brand of ice cream1.6 (1.0-2.9; p = 0.04)

Semarang, IndonesiaHygiene & sanitationNever or sometimes washing hands before eating3.97 1.22-12.93; p = 0.022) [22]
Hygiene & sanitationOpen sewage system or no drainage system in house7.19 (1.33-38.82; p = 0.022)
Socio-economicBeing unemployed or part-time jobber31.3 (3.08-317.4; p = 0.036)

Mekong Delta, VietnamLiving conditionRecent contact with typhoid fever case4.3 (1.4-13.4; p = 0.04) [17]
Socio-economicLow economic level2.5 (1.3-5.1; p = 0.01)

River Seine, Paris, FranceEating chicken on boat2.0 (0.3 – 13.7) [28]
Eating rice on boat2.9 (0.4 – 19.8)

Eastern Kolkata, IndiaUsing latrine in-house latrine for defecation5.32 (p = 0.9)[29]

Karachi, PakistanLiving in densely populated area2.43 (1.27 – 4.64; p = 0.01)[30]

Frozen mamey pulp imported from Guatemala used in fruit shake
Cig Kofte is a traditional raw food made from raw meat rolled in a ball form
MOR – Matched odds ratio
OR – Odds ratio
RR – Relative risk ratio.