| | Artificial sweetener | Brand/trade name | Main market | Chemical formula | ADI (g/kg/day) | Sweetening potential | Uses | Molar mass (g/mol) | Density (g/cm3) | Year of approval | Reference |
| | ASP | NutraSweet Equal | North America, Europe, Asia | C14H18N2O5 | 40 | 200 | Foods and beverages, pharmaceuticals, etc. | 294.3 | 1.347 | 1981 | Whitehouse et al., 2008 [45]; Fenge et al., 2013 [46]; Abu-Reidah [47] |
| | SAC | Sweet’N Low, Sweet Twin, Necta Sweet | America, Europe, Asia | C7H5NO3 | 5 | 300 | Soft drinks, tabletop sweeteners, and desserts | 183.2 | 0.83 | 1985 | Walter [46]; Feng et al., 2013 [48]; BeMiller [49] |
| | ACE | Sunett
Sweet One | North America, Europe, Asia | C4H4KNO4S | 15 | 200 | Table-top sweeteners, beverages, dairy products, confectionery, oral hygiene products, and pharmaceuticals | 163.15 | 1.83 | 1988 | Kuhn [50]; Lange et al. [51]; Zeece [52] |
| | NEO | Neotame | America | C20H24N2O5 | 0.3 | 7000 | Carbonated soft drinks, yogurts, cakes, drink powders, etc. | 378.46 | 1.13 | 2002 | Nabors [54]; Lange et al. [51]; Tiefenb-acher [53] |
| | SUC | Splenda | North America | C12H19Cl3O8 | 5 | 6000 | Diet foods and beverages | 397.64 | 1.69 | 1998 | Spillane [47]; Feng et al., 2013 [48]; Hughes and Dean [56] |
| | ALT | Aclame | Australia, Mexico, New Zealand, China | C14H25N3O4S | 1 | 2000 | Bakery products, snack foods, candies and confectionery, ice cream, and frozen dairy products | 331.43 | | Not approved by FDA, thus not used in USA and EU | Feng 2016 et al., 2013 [48]; Tiefenb-acher [53]; BeMiller [49] |
| | CYC | Twin Sweet | Europe, Asia | C6H12NNaO3S | 7 | 30 | Baked goods, confections, desserts, soft drinks, preserves, and salad dressings | 201.22 | 0.7 | 1984 banned in USA since 1970 | Lange et al., 2012 [51]; Chakrab-orty and Das, 2016 [57] |
| | NHDC | | Europe, Japan | C28H36O15 | 5 | 1900 | Flavoring agent or adjuvant, foods including condiments and seasonings, beverage, and pharmaceuticals | 612.6 | 1.6 | 1994 | Lange et al. [51]; Ashurst et al. [58] |
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