Research Article

Transcriptomic Profiling of Human Placental Trophoblasts in Response to Infection with Enterococcus faecalis

Table 1

Classification of DEGs according to their GO biological process categories.

TermGenes

Associated with apoptosis:
GO:0042981~regulation of apoptosis
GO:0006915~apoptosis
GO:0006917~induction of apoptosis
RTN4, IER3, XRCC2, ZMAT3, TNFSF15, PRDX5, PRDX2, PRDX3, FOXO3, ITSN1, CITED2, MEN1, MAP3K7, CASP6, ZFP91, CDKN2A, FNTA, BAG1, BOK, AEN, ZNF443, NET1, IP6K2, ADAM9, EGFR, SOCS3, AIFM1, RELA, TP53, ARHGEF17, JMY, ARHGEF11, CARD11, GRM4, SERPINB9, KRT18, NME3, PSEN1, TXNDC5, JUN, TNFAIP8, VEGFA, MAP3K10, KCNH8, DCUN1D3, CDK5R1, YWHAZ, GSDMA, XIAP, ERBB3, ADAMTSL4, NFKBIA, COL2A1, BCL2L1, CHEK2, GCH1, DDX19B, PPP2CB, LHX4, CD2, BCL3, BCL6, TAF9, TRAF6, PCSK6, BMF, ERCC1, TERF1, PHLDA1, HIP1, IL6, TP53BP2, KLF10, CREB1, BAD, GAS1, YWHAE, C14ORF153, NAE1, CDKN1A, TNFSF10, SON, NUPR1, BNIP3L, ID3, HSPD1, DNAJB6, BARD1, E2F1, SGPP1, ZNF346, CTNNB1, PAK2, GSN, RHOB, LOC100128086, ACIN1, EBAG9, SGK1, STAG3L3, DDIT4, PPM1F, EP300, MAPK7, GADD45B, GADD45A, GULP1, GPR65, DIDO1, TSC22D3, ECE1, PTPN6, PDCD10, RYBP, DUSP22, TNFSF9, ASAH2C (117)

Associated with stress and stimulus response:
GO:0006950~response to stress
GO:0042221~response to chemical stimulus
GO:0048583~regulation of response to stimulus
GO:0002237~response to molecule of bacterial origin
XRCC2, PDGFB, PDGFA, RBM3, TIRAP, FOXO3, KIAA0652, CITED2, MUTYH, GP6, INSIG2, LTB4R, CTGF, COL4A3BP, ZNF443, MAP2K7, ADAM9, EGFR, F11R, ATG9B, SOCS3, USP1, RELA, NEIL1, GAGE12G, SERPING1, GRHL3, DDIT4, PLAUR, RFC3, DCLRE1A, EP300, GAGE5, JUN, GAGE12I, LILRB3, VEGFA, KIAA1715, RYR1, DSP, AMFR, COL1A1, PLA2G2D, CCL3, ACHE, BLM, ERBB3, ALDOB, MAP4K1, BCL2L1, CHEK2, PXK, ITGB1, ARNT, DUSP19, ECE1, TFEC, C7ORF68, PTPN6, MAFF, RECQL5, CFB, MAP2K4, MYO1F, AGER, DDX58, HDAC5, APOL2, HYOU1, CDKN1A, ATF4, CXCL16, POLD2, PCNA, LOC732360, HSPD1, ENG, DNAJB6, ELF3, HPS6, FAM175A, ZMAT3, PRDX5, PMS2L5, PRDX2, PRDX3, PMS2L1, OS9, PMS2L3, MEN1, HMOX2, FOS, ANKRD17, CASP6, MCM7, HSF1, GSN, SLC23A2, XYLT1, AEN, IL1RAP, ERRFI1, FANCC, NLRP7, NFKBIZ, SGK1, SP100, AIFM1, GEN1, DDB1, CNPY3, LYZ, TP53, MMP14, WAS, JMY, C8G, CHST1, EYA3, RIF1, ADM, PSEN1, HIST2H2BE, MAP3 K10, GADD45B, GADD45A, TTRAP, YWHAZ, XIAP, C17ORF70, WRNIP1, MKNK2, EGLN2, EGLN1, COMT, VARS, TPM1, GCH1, IGSF10, CD9, CYP27B1, IL10RB, POU2F3, PPP2CB, BCL3, ENO3, NFATC4, BCL6, ERCC1, FEN1, HSPA8, IL6, ATRN, SIRT7, STAT3, NAE1, CCL11, VWF, NUPR1, TFRC, CSNK1E, TDP1, BNIP3L, ALKBH1, ID3, BARD1, SYT1, CTNNB1, FNTA, CHRNA5, RARA, PRKACB, BAIAP2, LIFR, SOCS7, GRB10, SLC25A36, PDGFRB, STC1, NFKBIA, IRAK3, NDRG1, TAF9, SRP54, KLF10, ABCG1, NR1I2, TSC1, LDLR, LEPR, GPR81, RHOQ, ASAH1, VN1R2, AES, CYR61, ADAM10, UFD1L, SS18, G6PC, CTSC, GNB4, DGKD, LOC100128775, DDX19B, COL6A2, PIK3R3, PIK3R1, CREB1, CAPN3, LEP, ID2, ID1, GNG10, RSRC1, ANXA11, MAPK15, TJP2, SBNO2, MAP3K7, ZFP91, AP2B1, PVRL2, SPG21, TRAF6, ATP6V1H, DUSP22, TRIM24, FOXP1, NPY5R, CARD11, NDEL1, AP2A1, IRF4, NCOR1 (235)

Associated with placenta and embryonic development:
GO:0043009~chordate embryonic development
GO:0009792~embryonic development ending in birth or egg hatching
GO:0001701~in utero embryonic development
GO:0001892~embryonic placenta development
GO:0001890~placenta development
XRCC2, COL2A1, EGLN1, BCL2L1, ITGB1, TPM1, CITED2, ARNT, MAP3K7, MEN1, OSR2, ECE1, HAND1, HSF1, COL4A3BP, PKD1, TRAF6, MAFF, ADAM10, MYO1E, GABPA, TP53, SPINT1, ICMT, MBNL1, GAS1, DVL1, HES1, ACVR2A, NDEL1, EP300, TSC1, PSMC4, PSEN1, MNX1, TGIF1, PDGFRB, LOC652826, COL1A1, RBPJ, VWF, CYP27B1, CCNF, PLCD3, PRDX3 (45)

Associated with cell adhesion:
GO:0007010~cytoskeleton organization
GO:0030036~actin cytoskeleton organization
GO:0007015~actin filament organization
GO:0007162~negative regulation of cell adhesion
GO:0010810~regulation of cell-substrate adhesion
GO:0001953~negative regulation of cell-matrix adhesion
GO:0032387~negative regulation of intracellular transport
ALDOA, CCL3, SHROOM4, PDGFB, VPS54, CALD1, SIPA1, CETN3, NEDD9, RHOQ, ITGB1, TPM1, TTLL3, CTNNB1, SPC25, PTK2, PRR5, PACSIN1, PAK2, ANK3, GSN, FBXO5, TEKT2, BCL6, FGD5, ARHGAP8, SNHG3-RCC1, FGD6, TNXA, FSCN2, CKAP5, LOC100132288, ARHGEF17, CAPN3, WAS, ARHGEF11, NCK2, SS18, NDEL1, LOC399942, SDCBP, HAUS8, NEURL2, CRK, GADD45A, NCOR1, DNAJB6, CDKN2A, ADAM10, ERBB3, MYO1F, COL1A1, MMP14, PIK3R1, TSC1, CYR61, RELL2, NFKBIE, NFKBIB, G3BP2, NFKBIA, BARD1 (62)

Associated with immune response:
GO:0002682~regulation of immune system process
GO:0002697~regulation of immune effector process
GO:0045321~leukocyte activation
GO:0042110~T cell activation
GO:0019221~cytokine-mediated signaling pathway
GO:0032655~regulation of interleukin-12 production
GO:0045075~regulation of interleukin-12 biosynthetic process
GO:0045084~positive regulation of interleukin-12 biosynthetic process
GO:0002711~positive regulation of T cell mediated immunity
GO:0007253~cytoplasmic sequestering of NF-kappaB
GO:0007249~I-kappaB kinase/NF-kappaB cascade
GO:0042347~negative regulation of NF-kappaB import into nucleus
GO:0009966~regulation of signal transduction
GO:0002757~immune response-activating signal transduction
HIST1H4 K, FOXO3, CDKN2A, PVRL2, HIST1H4E, SPG21, RARA, ACIN1, CFB, KLF10, BAD, C8G, CDKN1A, ID2, JUN, HSPD1, RBM15, ATP6V1H, SERPING1, FOXP1, DDX58, AP2B1, AP2A1, YWHAZ, SBNO2, ITGB1, BCL3, NDRG1, ERCC1, PIK3R1, ADAM9, ADAM10, MYO1F, HDAC5, IRF1, KIR3DL1, BLM, TP53, WAS, PKNOX1, CD2, PATZ1, IRF4, KIF13B, STAT4, KRT18, SP100, LIFR, STAT3, MAST2, NFKBIB, TIRAP, G3BP2, IRAK1BP1, EDARADD, VAPA, SLC20A1, PDGFB, EFNA1, CHMP5, LEPR, RGL3, FSTL3, TNFSF15, PRDX2, ITSN1, CITED2, CTNNB1, MAP3K7, MEN1, GPR89B, ZFP91, SPRY1, TBC1D14, GIT2, GPR89A, NET1, EGFR, SOCS3, RELA, SOCS7, ARHGEF17, SOCS4, DDIT4, ARHGEF11, CARD11, SPAG9, GRM4, ACVR2A, RALGAPA2, NCK2, GRB10, NDEL1, PSEN1, VEGFA, MAP3K10, TGIF1, TBC1D3G, SNX6, ERBB3, SIPA1, PPM1A, MAP4K1, TRIM13, TFG, NFKBIA, TIMP2, ARNT, TBC1D3B, RASAL2, IRAK3, DUSP19, ECE1, CYP27B1, TSPYL2, SLC35B2, PPP2CB, BCL6, FGD5, TRAF6, PCSK6, FGD6, RASA2, IL6, TBC1D10A, PAK1IP1, DUSP22, ICMT, RGS17, GAS1, TRIM24, DVL1, TBC1D25, LEP, TNFSF10, LRP1, TSC1, GRTP1, C6ORF170, NCOR1, CRK, ENG, TOB1