Digestive Enzyme Inhibition of Different Phenolic Fractions and Main Phenolic Compounds of Ultra-High-Pressure-Treated Palm Fruits: Interaction and Molecular Docking Analyses

Table 1

The interactions between catechin and caffeic acid on inhibition of pancreatic lipase.

Combination doses	Catechin	Caffeic acid	Inhibition ratio	CI^a	Fa^b	CI of Fa	Catechin	Caffeic acid
	Combination test (μg/mL)		(%)		(%)		Calculation at corresponding Fa (μg/mL)
1 : 2	45.0	90.0	13.70 ± 0.23	1.27	25.0	1.16	62.88	125.76
	60.0	120.0	21.00 ± 1.63	1.22	50.0	1.01	97.54	195.09
	75.0	135.0	32.30 ± 1.22	1.14	75.0	0.93	151.31	302.63
	90.0	185.0	46.17 ± 1.21	1.08	90.0	0.87	234.72	469.45
	105.0	210.0	55.76 ± 2.14	0.99
2 : 1	90.0	45.0	15.14 ± 1.36	1.24	25.0	1.17	121.38	60.69
	120.0	60.0	22.45 ± 1.99	1.19	50.0	0.98	190.72	95.36
	135.0	75.0	33.74 ± 2.10	1.10	75.0	0.87	299.68	149.84
	185.0	90.0	47.61 ± 1.82	1.05	90.0	0.83	470.89	235.44
	210.0	105.0	57.21 ± 2.53	0.92
1 : 1	90.0	90.0	41.64 ± 2.31	1.06	25.0	1.15	45.11	45.11
	120.0	120.0	54.10 ± 1.44	0.97	50.0	0.99	113.64	113.64
	135.0	135.0	57.40 ± 1.92	0.95	75.0	0.84	286.28	286.28
	185.0	185.0	64.28 ± 2.13	0.90	90.0	0.78	521.24	521.24
	210.0	210.0	66.43 ± 2.37	0.88

^aCI, combination index. CI ≤ 0.90, 0.90 < CI < 1.10, or CI ≥ 1.10 represent synergistic, additive, and antagonistic effects, respectively. ^bFa, fraction affected means the dose of combination of catechin and caffeic acid effect on inhibition rate. CI25, CI50, CI75, and CI90 represent the corresponding CI value when Fa is 25%, 50%, 75%, and 90%.