Research Article | Open Access
Muhammad Tariqus Salam, Mohamad Sawan, Dang Khoa Nguyen, "Low-Power Implantable Device for Onset Detection and Subsequent Treatment of Epileptic Seizures: A Review", Journal of Healthcare Engineering, vol. 1, Article ID 282767, 16 pages, 2010. https://doi.org/10.1260/2040-2222.214.171.124
Low-Power Implantable Device for Onset Detection and Subsequent Treatment of Epileptic Seizures: A Review
Over the past few years, there has been growing interest in neuro-responsive intracerebral local treatments of seizures, such as focal drug delivery, focal cooling, or electrical stimulation. This mode of treatment requires an effective intracerebral electroencephalographic acquisition system, seizure detector, brain stimulator, and wireless system that consume ultra-low power. This review focuses on alternative brain stimulation treatments for medically intractable epilepsy patients. We mainly discuss clinical studies of long-term responsive stimulation and suggest safer optimized therapeutic options for epilepsy. Finally, we conclude our study with the proposed low-power, implantable fully integrated device that automatically detects low-voltage fast activity ictal onsets and triggers focal treatment to disrupt seizure progression. The detection performance was verified using intracerebral electroencephalographic recordings from two patients with epilepsy. Further experimental validation of this prototype is underway.
- D. K. Nguyen and S. S. Spencer, “Invasive EEG in presurgical evaluation of epilepsy,” in The Treatment of Epilepsy, Chapter 53, pp. 633–658, Wiley-Blackwell, 2nd edition, 2004.
- E. J. Jerome, “Overview of surgical treatment for epilepsy,” in The Treatment of Epilepsy, Chapter 60, pp. 743–756, Wiley-Blackwell, 3rd edition, 2009.
- S. C. Schachter, J. Guttag, S. J. Schiff, D. L. Schomer, and Summit Contributors, “Advances in the Application of Technology to Epilepsy: The CIMIT/NIO Epilepsy Innovation Summit,” Epilepsy & Behavior, vol. 16, pp. 3–46, 2009.
- I. Osorio, M. G. Frei, S. Sunderam et al., “Automated seizure abatement in humans using electrical stimulation,” Annals of Neurology, vol. 57, no. 2, pp. 258–68, 2005.
- E. H. Kossoff, E. K. Ritzl, J. M. Politsky et al., “Effect of an external responsive neurostimulator on seizures and electrographic discharges during subdural electrode monitoring,” Epilepsia, vol. 45, pp. 1560–1567, 2004.
- P. E. McSharry, T. He, L. A. Smith, and L. Tarassenko, “Linear and non-linear methods for automatic seizure detection in scalp electro-encephalogram recordings,” Medical & biological engineering & computing, vol. 40, no. 4, pp. 447–461, 2002.
- A. Shoeb, H. Edwards, J. Connolly, B. Bourgeois, T. Treves, and J. Guttag, “Patient-Specific Seizure Onset Detection,” Engineering in Medicine and Biology Society, vol. 5, no. 4, pp. 483–498, 2004.
- P. Suffczynski, F. H. L. Da Silva, J. Parra et al., “Dynamics of epileptic phenomena determined from statistics of ictal transitions,” IEEE Transactions on Biomedical Engineering, vol. 53, no. 3, pp. 524–532, 2006.
- K. Moxon, V. Kuzmick, J. Lafferty et al., “Real-time seizure detection system using multiple single-neuron recordings,” in Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp. 934–937, Turkey, 2001.
- L. D. Iasemidis, S. Deng-Shan, W. Chaovalitwongse et al., “Adaptive epileptic seizure prediction system,” IEEE Transactions on Biomedical Engineering, vol. 50, pp. 616–627, 2003.
- L. D. Iasemidis, P. M. Pardalos, D. S. Shiau et al., “Prediction of human epileptic seizures based on optimization and phase changes of brain electrical activity,” J. Optimization Methods and Software, vol. 18, pp. 81–104, 2003.
- F. Mormann, K. Lehnertz, P. David, and C. E. Elger, “Mean phase coherence as a measure for phase synchronization and its application to the EEG of epilepsy patients,” Elsevier Science, vol. 144, pp. 358–369, 2000.
- R. Tetzlaff, C. Niederhofer, and P. Fischer, “Automated detection of a preseizure state: nonlinear EEG analysis in epilepsy by cellular nonlinear networks and Volterra systems,” International Journal of Circuit Theory and Applications, vol. 34, pp. 89–108, 2006.
- J. Arnhold, P. Grassberger, K. Lehnertz, and C. E. Elger, “A robust method for detecting interdependences: application to intracranially recorded EEG,” Physica D: Nonlinear Phenomena, vol. 134, pp. 419–430, 1999.
- S. Nagaraj, A. Shah, P. Shah, V. Szeto, and M. T. Bergen, “Ambulatory preseizure detection device,” in IEEE 32nd Annual Northeast Bioengineering Conference, pp. 41–42, Easton, PA, USA, 2006.
- G. Sukhi and G. Jean, “An automatic warning system for epileptic seizures recorded on intracerebral EEGs,” Clinical neurophysiology, vol. 116, pp. 2460–2472, 2005.
- R. Yadav, R. Agarwal, and M. N. S. Swamy, “A novel dual-stage classifier for automatic detection of epileptic seizures,” in Engineering in Medicine and Biology Society, 30th Annual International Conference of the IEEE, pp. 911–914, 2008.
- N. C. Bhavaraju, M. G. Frei, and I. Osorio, “Analog seizure detection and performance evaluation,” IEEE transactions on bio-medical engineering, vol. 53, pp. 238–245, 2006.
- M. T. Salam, M. Sawan, A. Hamoui, and D. K. Nguyen, “Low-power CMOS-based epileptic seizure onset detector,” in IEEE-NEWCAS, French, 2009.
- M. T. Salam, M. Sawan, D. K. Nguyen, and A. A. Hamoui, “Epileptic Low-Voltage Fast-Activity Seizure-Onset Detector,” in IEEE-BIOCAS: special session, China, 2009.
- W. H. Theodore and R. S. Fisher, “Brain stimulation for epilepsy,” Neurology, vol. 3, no. 8, pp. 111–118, 2004.
- T. L. Skarpaas and M. J. Morrell, “Intracranial stimulation therapy for epilepsy,” Neurotherapeutics, vol. 6, no. 2, pp. 238–43, 2009.
- J. Coulombe, M. Sawan, and J. F. Gervais, “A Highly Flexible System for Microstimulation of the Visual Cortex: Design and Implementation,” IEEE Trans. Biom. Circuits & Systems, vol. 1, pp. 258–269, 2007.
- F. Mounaim, M. Sawan, and S. Bedard, “Implantable Neuro-Monito-Stimulation System Dedicated to Enhance the Bladder Functions,” in IEEE Biomedical Circuits and Systems Conference - Healthcare Technology, pp. 198–201, London, UK, 2006.
- P. Nadeau and M. Sawan, “A flexible high voltage biphasic current-controlled stimulator,” in Conference on Biomedical Circuits and Systems, pp. 206–209, 2006.
- A. G. Stein, H. G. Eder, D. E. Blum, A. Drachev, and R. S. Fisher, “An automated drug delivery system for focal epilepsy,” Epilepsy research, vol. 39, pp. 103–114, 2000.
- J. A. David, E. Ortega, and S. F. Robert, “Diazepam prophylaxis for bicuculline-induced seizures: a rat dose-response model,” Neuroscience Letters, vol. 356, pp. 66–68, 2004.
- R. S. Fisher and J. Ho, “Potential new methods for antiepileptic drug delivery,” CNS drugs, vol. 16, no. 9, pp. 579–593, 2002.
- J. Oommena, A. C. Krausb, and R. S. Fisher, “Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold,” Neuroscience Letters, vol. 417, pp. 308–311, 2007.
- D. J. Anschel, E. L. Ortega, A. C. Kraus, and R. S. Fisher, “Focally injected adenosine prevents seizures in the rat,” Experimental Neurology, vol. 190, pp. 544–547, 2004.
- B. Katz and R. Miledi, “The effect of temperature on the synaptic delay at the neuromuscular junction,” J. Physiol, vol. 181, pp. 656–670, 1965.
- S. M. Thompson, L. M. Masukawa, and D. A. Prince, “Temperature dependence of intrinsic membrane properties and synaptic potentials in hippocampal CA1 neurons in vitro,” J Neurosci, vol. 5, pp. 817–824, 1985.
- M. Volgushev, T. R. Vidyasagar, M. Chistiakova, T. Yousef, and U. T. Eysel, “Membrane properties and spike generation in rat visual cortical cells during reversible cooling,” J Physiol (London), vol. 522, Pt. 1, pp. 59–76, 2000.
- Y. Xiao-Feng, D. W. Duffy, R. E. Morley, and S. M. Rothman, “Neocortical seizure termination by focal cooling: Temperature dependence and automated seizure detection,” Epilepsia, vol. 43, pp. 240–245, 2002.
- N. Tanaka, M. Fujii, H. Imoto et al., “Effective suppression of hippocampal seizures in rats by direct hippocampal cooling with a Peltier chip,” J Neurosurg, vol. 108, no. 4, pp. 791–797, 2008.
- S. M. Rothman, M. D. Smyth, X. F. Yang, and G. P. Peterson, “Focal cooling for epilepsy: an alternative therapy that might actually work,” Epilepsy Behav, vol. 7, pp. 214–221, 2005.
- F. Rychlicki, N. Zamponi, R. Trignani, R. A. Ricciuti, M. Iacoangeli, and M. Scerrati, “Vagus nerve stimulation: clinical experience in drug-resistant pediatric epileptic patients,” Seizure, vol. 15, no. 7, pp. 483–490, 2006.
- N. Sethi, D. Labar, L. Ponticello, J. Torgovnick, P. Sethi, and E. Arsura, “Treatment of Medically Refractory Epilepsy: A Review Of Vagus Nerve Stimulator,” The Internet Journal of Neurology, vol. 9, no. 1, 2008.
- M. Morrell, “Brain stimulation for epilepsy: can scheduled or responsive neurostimulation stop seizures?” Neurology, pp. 164–168, 2006.
- P. Boon, R. Raedt, V. de Herdt, T. Wyckhuys, and K. Vonck, “Electrical stimulation for the treatment of epilepsy,” Neurotherapeutics, vol. 6, no. 2, pp. 218–27, 2009.
- B. Gosselin, P. Y. Robert, and M. Sawan, “A Scalable Design for Signal Conditioning and Digitization in Implantable Multi-Channel Neural Sensors,” in Computer Architecture for Machine Perception and Sensing, International Workshop, pp. 73–74, 2007.
- B. Gosselin and M. Sawan, “A low-power integrated neural interface with digital spike detection and isolation,” in 14th IEEE International Conference on Electronics, Circuits and Systems, Marrakech, Morocco, 2007.
- B. Gosselin and M. Sawan, “An ultra low-power CMOS action potential detector,” in IEEE International Symposium on Circuits and Systems, Seattle, WA, 2008.
- B. Gosselin, V. Simard, J. F. Roy, W. Marrouche, C. Dumortier, and M. Sawan, “Multichannel wireless cortical recording: Circuits, system design and assembly challenges,” in IEEE International Workshop on Biomedical Circuits and Systems, Singapore, 2004.
- B. Gosselin, V. Simard, and M. Sawan, “Low-power implantable microsystem intended to multichannel cortical recording,” in IEEE International Symposium on Circuits and Systems, Vancouver, BC, Canada, 2004.
- B. Gosselin, V. Simard, and M. Sawan, “An ultra low-power chopper stabilized front-end for multichannel cortical signals recording,” in IEEE CCECE, pp. 2259–2262, 2004.
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