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Journal of Healthcare Engineering
Volume 3, Issue 4, Pages 551-569
Research Article

Information-Guided Surgery of Intracranial Gliomas: Overview of an Advanced Intraoperative Technology

Yoshihiro Muragaki,1,2 Mikhail Chernov,1,2 Kitaro Yoshimitsu,1 Takashi Suzuki,1 Hiroshi Iseki,1,2 Takashi Maruyama,1,2 Manabu Tamura,1,2 Soko Ikuta,1 Masayuki Nitta,1 Atsushi Watanabe,1 Taiichi Saito,1,2 Jun Okamoto,1 Chiharu Niki,1 Motohiro Hayashi,1,2 and Kintomo Takakura1,2

1Faculty of Advanced Techno-Surgery, Tokyo Women’s Medical University, Tokyo, Japan
2Department of Neurosurgery, Tokyo Women’s Medical University, Tokyo, Japan

Received 1 November 2011; Accepted 1 August 2012

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objective of this paper is to provide an overview of advanced information-guided surgical management technology of intracranial gliomas implemented in Japan, represented by the Intelligent Operating Theater at the Tokyo Women’s Medical University, established in 2000, where more than 1000 patients with various intracranial pathology have received neurosurgical treatment with application of the intraoperative MRI, updated neuronavigation, and advanced neurophysiological and histopathological monitoring. Additionally, a dedicated computer-based system for accumulating, storing, integrating, and analyzing various surgical data was developed, which provided an opportunity for adequate risk management and prediction of the surgical results. Application of these modalities and tools led to significant improvements in both surgical outcome and long-term patients’ prognosis. Further technological developments, such as new therapeutic robot, dedicated laser, and high intensity focused ultrasound are currently under investigation. The final goal is to integrate all these devices and systems into comprehensive neurosurgical framework.