Accumulation of Phase-Shift Nanoemulsions to Enhance MR-Guided Ultrasound-Mediated Tumor Ablation In Vivo

Kopechek, Jonathan A.; Park, Eunjoo; Mei, Chang-Sheng; McDannold, Nathan J.; Porter, Tyrone M.

doi:https://doi.org/10.1260/2040-2295.4.1.109

Journal of Healthcare Engineering

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Research Article | Open Access

Volume 4 | Article ID 305064 | https://doi.org/10.1260/2040-2295.4.1.109

Accumulation of Phase-Shift Nanoemulsions to Enhance MR-Guided Ultrasound-Mediated Tumor Ablation In Vivo

Jonathan A. Kopechek,¹Eunjoo Park,²Chang-Sheng Mei,²Nathan J. McDannold,²and Tyrone M. Porter^1,3

Received01 Aug 2012

Accepted01 Nov 2012

Abstract

Magnetic resonance-guided high intensity focused ultrasound (MRgHIFU) is being explored as a non-invasive technology to treat solid tumors. However, the clinical use of HIFU for tumor ablation applications is currently limited by the long treatment times required. Phase-shift nanoemulsions (PSNE), consisting of liquid perfluorocarbon droplets that can be vaporized into microbubbles, are being developed to accelerate HIFU-mediated heating. The purpose of this study was to examine accumulation of PSNE in intramuscular rabbit tumors in vivo. MR images were acquired before and after intravenous injection of gadolinium-containing PSNE. MR signal enhancement was observed in rabbit tumors up to six hours after injection, indicating that PSNE accumulated in the tumors. In addition, PSNE vaporization was detected in the tumor with B-mode ultrasound imaging, and MR thermometry measurements indicated that PSNE accelerated the rate of HIFU-mediated heating. These results suggest that PSNE could dramatically improve the efficiency and clinical feasibility of MRgHIFU.

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